Garry Gold
Effects of an herbal topical cream on osteoarthritis symptoms, biomarkers, and disease progression in the knee
Contact Information
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Brief
Arthritis Relief Plus (ARP) Cream is a natural, herbal cream that has been shown to provide pain relief and decreased stiffness. Anecdotal reports suggest that pain may continue to be reduced months after cream use is stopped, indicating that there could be some disease-modifying effects of the cream. The purpose of this study is to test the claim that the ARP cream cream can provide long-term pain relief to osteoarthritis patients after only a short period of use. The study will also try to determine whether the pain relief is accompanied with any measurable indications that the progression of osteoarthritis has slowed or halted.
Recruiting Status:
No longer recruitingStanford Recruiting Status:
No longer recruitingCondition(s):
Intervention(s):
- Drug: herbal topical cream
Phase:
N/AEligibility
Ages Eligible for Study:
40 years to 70 yearsGenders Eligible for Study:
Male and FemaleHealth of Volunteers:
People with the conditions listed in this trial can participate as controls.Key Inclusion Criteria:
-Men and women between 40-70 years old
-Have a history of knee pain
-Exhibit mild osteoarthritis on the knee, as determined by Dr. Gold through MRIs and radiographs (if available).
Key Exclusion Criteria:
-Outside of age range
-Prior knee surgery
-History of knee or knee ligament instability
-History of intermittent or persistent knee joint swelling
-History of trauma to the knee or lower extremities resulting in fracture, tears of menisci, ligaments or joint capsule, or cartilage damage
-Unable to have MRI scan due to the presence of metallic internal devices that would represent a risk factor for MRI and known or suspected pregnancy.
History of corticosteroid use
-Kidney Disease
-Knee diameter greater than 17cm and body diameter greater than 60 cm due to the physical constraints of the MRI
Additional Study Details
Official Title:
Effects of an herbal topical cream on osteoarthritis symptoms, biomarkers, and disease progression in the kneeAnticipated start date:
12/10/2008Lead Sponsor:
Stanford UniversityInvestigator(s):
- Anne L. Friedlander
- Garry Evan Gold
- Omer Parvez Shah
- Jill Fattor
- Brian Andrew Hargreaves
- Ernesto Staroswiecki
- Seungbum Koo
Study Type:
InterventionalPurpose:
TreatmentAllocation:
Non-randomizedMasking:
Double BlindControl:
noneAssignment:
ParallelEndpoints:
EfficacyPrimary Outcomes:
- WOMAC
Secondary Outcomes:
- Function
- MRI morphology
- Blood and urine biomarkers
Total Number to be Enrolled:
40Total Number to be Enrolled at Stanford:
40More Information
Secondary ID(s):
- Protocol ID:14764
Locations & Contacts
Stanford Locations & Contacts:
Stanford University School of Medicine 300 Pasteur Drive Stanford, CA 94305Non-Stanford Locations:
The Stanford website does not have any locations outside of Stanford listed for this trial. You may want to check clinicaltrials.gov for posible additional locations.
This listing was last updated:
10/27/2009PLEASE NOTE:
Study Coordinators and Research Nurses cannot give medical advice over the phone. Telephone numbers are provided for obtaining additional information on specific clinical research trials only. If you have specific questions which require clinical expertise, please call your primary care physician. If you do not have a primary care physician please feel free to call the SHC Physician Referral Service at (800) 756-9000 or send an email.
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