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Bioengineering
Zev Bryant Info

Zev Bryant

Email:
Profile: http://med.stanford.edu/profiles/Zev_Bryant/
Academic Appointments
Appointment
Organization
Assistant Professor
Bioengineering
Assistant Professor (By courtesy)
Structural Biology
Member
Bio-X
Graduate & Fellowship Program Affiliations
Bioengineering ; Biophysics ;
 
Honors & Awards
Title
Organization
Date(s)
Predoctoral Fellowship
Howard Hughes Medical Institute
1999
Harold M. Weintraub Award
FHCRC
2004
Alan Bearden Award
UC, Berkeley
2004
Postdoctoral Fellowship
Helen Hay Whitney Foundation
2005
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.Sc.
University of Washington
Biochemistry
1998
Ph.D.
UC, Berkeley
Molecular and Cell Biology
2003
Research Interests

Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. We use single molecule tracking and manipulation techniques to observe and perturb substeps in the mechanochemical cycles of individual motors. Protein engineering helps us to explore relationships between molecular structures and mechanical functions. Broad topics of current interest include torque generation by DNA-associated ATPases and mechanical adaptations of unconventional myosins.

Publications
  • Nöllmann M, Stone MD, Bryant Z, Gore J, Crisona NJ, Hong SC, Mitelheiser S, Maxwell A, Bustamante C, Cozzarelli NR "Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque." Nat Struct Mol Biol 2007; More »
  • Bryant Z, Altman D, Spudich JA "The power stroke of myosin VI and the basis of reverse directionality." Proc Natl Acad Sci U S A 2007; 104: 3: 772-7 More »
  • Gore J, Bryant Z, Nöllmann M, Le MU, Cozzarelli NR, Bustamante C "DNA overwinds when stretched." Nature 2006; 442: 7104: 836-9 More »
  • Gore J, Bryant Z, Stone MD, Nöllmann M, Cozzarelli NR, Bustamante C "Mechanochemical analysis of DNA gyrase using rotor bead tracking." Nature 2006; 439: 7072: 100-4 More »
  • Bryant Z, Stone MD, Gore J, Smith SB, Cozzarelli NR, Bustamante C "Structural transitions and elasticity from torque measurements on DNA." Nature 2003; 424: 6946: 338-41 More »
11 publications:   view full list