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Jennifer R. Cochran
Academic Appointments
Appointment
Organization
Assistant Professor
Member
Member
Graduate & Fellowship Program Affiliations
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Honors & Awards
Title
Organization
Date(s)
McCormick Award
McCormick Foundation
2007
Mallinckrodt Award
Edward Mallinckrodt Jr. Foundation
2007
Kimmel Scholars Award
Sidney Kimmel Foundation
2007
Translational Partnership Award
Wallace H. Coulter Foundation
2006, 2007
Howard Temin Award
NIH / National Cancer Institute
2004
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Postdoctoral Fellow
MIT
Biological Engineering
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Ph. D.
MIT
Biological Chemistry
2001
B.S.
University of Delaware
Biochemistry
1995
Research Interests
The Cochran laboratory uses interdisciplinary approaches in chemistry, engineering, and biophysics to study complex biological systems. Our main goals are to develop new technologies for basic science and biomedical applications. Clinical applications of our research involve bone and wound healing, biomimetic corneas, neural cell regeneration, and cancer imaging and therapy. Our research is driven by the philosophy that in order to control physiological processes it is necessary to understand the molecular mechanisms that drive these processes. We are interested in elucidating molecular details of receptor-mediated cell signaling events; at the same time developing protein and polymer-based tools that will allow us to manipulate cellular processes on a molecular level. For biomedical applications, we are combining rational design and combinatorial methods to create designer protein therapeutics and diagnostic agents. One such example is highlighted in a recent press release: http://news-service.stanford.edu/news/2006/may24/cochran-052406.html.
Publications
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Myung D,
Koh W, Bakri A, Zhang F, Marshall A, Ko J, Noolandi J, Carrasco M, Cochran JR, Frank CW, Ta CN
"Design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct."
Biomed Microdevices
2007;
More »
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Cochran JR,
Kim YS, Lippow SM, Rao B, Wittrup KD
"Improved mutants from directed evolution are biased to orthologous substitutions"
Protein Engineering, Design and Selection
2006;
19:
245-53
More »
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Cochran JR,
Kim YS, Olsen MJ, Bhandari R, Wittrup KD
"Domain-level antibody epitope mapping through yeast surface display of epidermal growth factor receptor fragments."
J Immunol Methods
2004;
287:
1-2:
147-58
More »
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Johns TG,
Adams TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ, Kim YS, Rothacker J, Nice EC, Walker F, Ritter G, Jungbluth AA, Old LJ, Ward CW, Burgess AW, Wittrup KD, Scott AM
"Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor."
J Biol Chem
2004;
279:
29:
30375-84
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Feldhaus MJ,
Siegel RW, Opresko LK, Coleman JR, Feldhaus JM, Yeung YA, Cochran JR, Heinzelman P, Colby D, Swers J, Graff C, Wiley HS, Wittrup KD
"Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library."
Nat Biotechnol
2003;
21:
2:
163-70
More »
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