{"result":[{"lastName":"Pfeffer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4087&type=small&showNoImage","displayName":"Suzanne Pfeffer","firstName":"Suzanne","href":"http://med.stanford.edu/profiles/Suzanne_Pfeffer","researchInterest":"The goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events.  We also study how cells acquire cholesterol from the diet and from LDL."},{"lastName":"Meyer","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4007&type=small&showNoImage","displayName":"Tobias Meyer","firstName":"Tobias","href":"http://med.stanford.edu/profiles/Tobias_Meyer","researchInterest":"CELLULAR INFORMATION PROCESSING  The main problem in signal transduction is to understand how different receptor-stimuli specifically control diverse cell functions. We are using automated microscopy, live-cell fluorescent biosensors and perturbations of predicted signaling proteins to systematically dissect signaling networks.  This allows us to identify signaling modules and to elucidate and ultimately model the flow of cellular information."},{"lastName":"Mochly-Rosen","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4256&type=small&showNoImage","displayName":"Daria Mochly-Rosen","firstName":"Daria","href":"http://med.stanford.edu/profiles/Daria_Mochly-Rosen","researchInterest":"Two areas:  1. Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling.  We focus on protein kinase C (PKC)-mediated signal transduction and on mitochondrial dynamics in several disease models. 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, we study their involvement  in normal cells and in models of human diseases."},{"lastName":"Teruel","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Chemical and Systems Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Assistant Professor,Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14171&type=small&showNoImage","displayName":"Mary Frances Nunez Teruel","firstName":"Mary","href":"http://med.stanford.edu/profiles/Mary_Teruel","researchInterest":"The Teruel Lab uses a combination of engineering and biological approaches including high-throughput screening of RNAi and DNA construct libraries, targeted mass spectrometry, live-cell fluorescence microscopy, and bioinformatics to investigate the systems biology of cell differentiation and cell signaling with particular focus on uncovering the molecular mechanisms underlying insulin resistance, diabetes, and obesity."},{"lastName":"Strick","clinicalFocus":[],"appointments":[{"appointment":"Health & Safety Specialist,Administrative Units - EH&S Program Management and Administration"}],"primaryAppointment":"Health & Safety Specialist,Administrative Units - EH&S Program Management and Administration","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9209&type=small&showNoImage","displayName":"David J. Strick, Ph.D.","firstName":"David","href":"http://med.stanford.edu/profiles/David_Strick","researchInterest":"My work is aimed at understanding cell signaling mechanisms that regulate the phagocytosis pathway in retinal pigment epithelium (RPE) cells. Loss of RPE phagocytic function leads to severe retinal degeneration in mouse models and retinitis pigmentosa in humans. Understanding these pathways will provide valuable insight into further treatments for retinal degenerative diseases."},{"lastName":"Quarta","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences"}],"primaryAppointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=14146&type=small&showNoImage","displayName":"Marco Quarta","firstName":"Marco","href":"http://med.stanford.edu/profiles/Marco_Quarta","researchInterest":""},{"lastName":"Stockdale","clinicalFocus":[{"focus":"Breast Cancer - Medical Oncology"},{"focus":"Oncology"},{"focus":"Newly Diagnosed Breast Cancer"},{"focus":"Metastatic Breast Cancer"},{"focus":"Inflammatory Breast Cancer"},{"focus":"Locally Advanced Breast Cancer"},{"focus":"Chemotherapy, Adjuvant"},{"focus":"Ductal Carcinoma In Situ"},{"focus":"Phyllodes Tumor"}],"appointments":[{"appointment":"Professor Emeritus,Medicine - Oncology"},{"appointment":"Emeritus Faculty, Acad Council,Medicine - Oncology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor Emeritus,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4528&type=small&showNoImage","displayName":"Frank E. Stockdale","firstName":"Frank","href":"http://med.stanford.edu/profiles/Frank_Stockdale","researchInterest":"Laboratory and clinical research in breast cancer ; Normal and abornal differentiation and growth"},{"lastName":"Wong","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","displayName":"Albert J. Wong, M.D.","firstName":"Albert","href":"http://med.stanford.edu/profiles/Albert_Wong","researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective."},{"lastName":"Hayer","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Chemical and Systems Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Chemical and Systems Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15969&type=small&showNoImage","displayName":"Arnold Hayer","firstName":"Arnold","href":"http://med.stanford.edu/profiles/Arnold_Hayer","researchInterest":""},{"lastName":"Fisher","clinicalFocus":[{"focus":"Medical Oncology"},{"focus":"Oncology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Medicine - Oncology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor - Med Center Line,Medicine - Oncology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4644&type=small&showNoImage","displayName":"George A. Fisher Jr.","firstName":"George","href":"http://med.stanford.edu/profiles/George_Fisher","researchInterest":"Clinical expertise in GI cancers with research which emphasizes Phase I and II clinical trials of novel therapies but also includes translational studies including biomarkers, molecular imaging, tumor immunology and development of immunotherapeutic trials."},{"lastName":"Burridge","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=23495&type=small&showNoImage","displayName":"Paul Burridge","firstName":"Paul","href":"http://med.stanford.edu/profiles/Paul_Burridge","researchInterest":"Cardiac differentiation of human induced pluripotent stem cells using developmental biology paradigms, chemically defined reprogramming, culture, and differentiation, disease modeling, cardiotoxicity, electrophysiology"},{"lastName":"Harel","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Genetics"}],"primaryAppointment":"Postdoctoral Research fellow, Genetics","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=37895&type=small&showNoImage","displayName":"Itamar Harel","firstName":"Itamar","href":"http://med.stanford.edu/profiles/Itamar_Harel","researchInterest":"The overarching goal of the Brunet lab is to understand the genetic mechanisms of aging and longevity. Aging is a highly plastic process regulated by a combination of genetic and environmental factors. \r\n\r\nI am interested in the basic molecular components that characterize \u0093young\u0094 and \u0093aged\u0094 cellular states. Aging is associated with an increased onset of cancer, and I seeks to define the set of factors that can rejuvenate an aged cell, without the risk of malignant transformation. Ultimately, w"},{"lastName":"Giaccia","clinicalFocus":[],"appointments":[{"appointment":"Professor,Radiation Oncology - Radiation and Cancer Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Obstetrics & Gynecology"},{"appointment":"Professor (By courtesy),Surgery"}],"primaryAppointment":"Professor,Radiation Oncology - Radiation and Cancer Biology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4141&type=small&showNoImage","displayName":"Amato J. Giaccia","firstName":"Amato","href":"http://med.stanford.edu/profiles/Amato_Giaccia","researchInterest":"During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically."},{"lastName":"Pearce","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Postdoctoral Research fellow, Biology (School of Humanities and Sciences)","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=11474&type=small&showNoImage","displayName":"Margaret Pearce","firstName":"Margaret","href":"http://med.stanford.edu/profiles/Margaret_Pearce","researchInterest":""},{"lastName":"Assad Kahn","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurosurgery"}],"primaryAppointment":"Postdoctoral Research fellow, Neurosurgery","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=37701&type=small&showNoImage","displayName":"Suzana Kahn","firstName":"Suzana","href":"http://med.stanford.edu/profiles/Suzana_Assad Kahn","researchInterest":""},{"lastName":"Nguyen","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Stanford Cancer Institute"}],"primaryAppointment":"Postdoctoral Research fellow, Stanford Cancer Institute","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=24227&type=small&showNoImage","displayName":"Le Xuan Truong Nguyen","firstName":"Le Xuan Truong","href":"http://med.stanford.edu/profiles/Le Xuan Truong_Nguyen","researchInterest":""},{"lastName":"Lan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"primaryAppointment":"Postdoctoral Research fellow, Radiology","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=13653&type=small&showNoImage","displayName":"Feng Lan","firstName":"Feng","href":"http://med.stanford.edu/profiles/Feng_Lan","researchInterest":""},{"lastName":"Ho","clinicalFocus":[],"appointments":[{"appointment":"Basic Life Science Research Associate,Microbiology & Immunology - Baxter Laboratory"}],"primaryAppointment":"Basic Life Science Research Associate,Microbiology & Immunology - Baxter Laboratory","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20984&type=small&showNoImage","displayName":"Andrew T.V. Ho","firstName":"Tri Van","href":"http://med.stanford.edu/profiles/Tri Van_Ho","researchInterest":""},{"lastName":"de Morree","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences"}],"primaryAppointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=20933&type=small&showNoImage","displayName":"Antoine de Morree","firstName":"Antoine","href":"http://med.stanford.edu/profiles/Antoine_de Morree","researchInterest":"Molecular mechanisms underlying neuromuscular disorders and the molecular regulation of satellite cell quiescence and activation in relation to normal aging."}]}