Scientific Focus
Research Interests
My main research interest lies in the functional anatomy of the urogenital system particularly in the human. We are using numerous histochemical and immunocytochemical methods to establish the normal pattern and type of autonomic nerve which supply selected regions of the urogenital system including the urinary bladder, ureter and prostate. This data forms the basis of comparison with the results obtained using the same experimental techniques on postoperative samples of refluxing ureters and prostate hypertrophy. Recently we have begun a detailed study on the morphology of the urethral sphincter mechanism particularly in relation to its functional significance in female urinary continence.
We have also begun a study on the structure and autonomic innervation of the detrusor in cases of bladder extrophy. Our objective is to correlate morphology with detrusor function following surgical correction of this clinical condition. This investigation is intended to identify prior to surgery those cases which are most likely to benefit from subsequent operative treatment.
Publications
- Ultrastructure of the bladder in classic exstrophy: correlation with development of continence. J Urol. 2004; (4 Pt 1): 1446-9; discussion 1449
- Correlation between the structure and function of the rabbit urinary bladder following partial outlet obstruction. J Urol. 2000; (4): 1349-56
- The distribution of noradrenergic nerves in the human lower urinary tract. A review. Eur Urol. 1999: 23-30
- Nitric oxide synthase and tyrosine hydroxylase are colocalized in nerves supplying the postnatal human male genitourinary organs. J Urol. 1996; (3): 1117-21
- Immunohistochemical localization of neuromarkers and neuropeptides in human fetal and neonatal urinary bladder. Br J Urol. 1995; (2): 230-5
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