Zhen Cheng

Administrative Appointments

• Member, Canary Center at Stanford for Cancer Early Detection (2009 - present)
• Member, Stanford Cancer Center (2007 - present)
• Member, Bio-X Program (2007 - present)
• Member, Molecular Imaging Program at Stanford (MIPS) (2007 - present)

Honors and Awards

• Best Basic Science Paper Published in 209, Journal of Nuclear Medicine (2010)
• New Investigator Award, Department of Defense (2009)
• Young Investigator Award, Melanoma Research Alliance (2009)
• IDEA Award, California Breast Cancer Research Program (2008)

Professional Education

Postdoctoral Advisees

Kai Cheng,  Hongguang Liu,  Yang Liu

Internet Links

• Cancer Molecular Imaging Chemistry Laboratory

Current Research Interests

The overall objective of my laboratory is to develop novel molecular imaging probes and techniques for non-invasive detection of cancer and its metastasis at the earliest stage, so that cancer can be cured or transformed into a chronic, manageable disease. The techniques developed in my research will allow a close examination of the molecular, metabolic and physiological characteristics of cancers and their responses to therapy. In order to achieve this goal, my lab is aimed to identify novel cancer biomarkers with significant clinical relevance, develop new chemistry for probes preparation, and validate new strategies for probes high-throughput screening.

Publications

• (177)Lu-DO3A-HSA-Z (EGFR:1907): characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas. Hoppmann S, Qi S, Miao Z, Liu H, Jiang H, Cutler CS, Bao A, Cheng Z. J Biol Inorg Chem. 2012
• 111In-Labeled Agouti Related Proteins for SPECT/CT Imaging of Tumor αvβ3 Integrin. Jiang L, Miao Z, Kimura RH, Ren G, Liu HG, Silverman AP, Li PY, Gambhir SS, Cochran JR, Cheng Z.. Journal of Biomedicine and Biotechnology. 2012: 2012 doi:10.1155/2012/ 36
• A multimodality reporter gene for monitoring transplanted stem cells. Pei Z, Lan X, Cheng Z, Qin C, Wang P, He Y, Yen TC, Tian Y, Mghanga FP, Zhang Y. Nucl Med Biol. 2012
• A novel clinically translatable fluorescent nanoparticle for targeted molecular imaging of tumors in living subjects. Gao J, Chen K, Luong R, Bouley DM, Mao H, Qiao T, Gambhir SS, Cheng Z. Nano Lett. 2012; 12 (1): 281-6
• Analysis of in situ and ex vivo αVβ3 integrin expression during experimental carotid atherogenesis. Yao Y, Jiang Y, Sheng Z, Zhang Y, An Y, Yan F, Ma G, Liu N, Teng G, Cheng Z. Int J Nanomedicine. 2012: 7 641-9