Daniel V. Madison
Academic Appointments
Appointment
Organization
Associate Professor
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Honors & Awards
Title
Organization
Date(s)
Young Investigator Award
Society for Neuroscience
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Lucille P. Markey Scholar
Lucile P. Markey Charitable Trust
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Administrative Appointments
Title
Organization
Start Year
End Year
Chair, Admissions Committee
Dept. Molecular and Cellular Physiology
2005
2007
Senator at large
Medical School Faculty Senate
2004
2006
Director of Admissions
Neurosciences Graduate Program
1997
2003
Executive Committee
Neurosciences Graduate Program
1995
2003
MSTP Admissions Committee
MSTP
1995
1999
9 appointments: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
Univ.of Calif. San Francisco
Neurosciences
1984
B.S.
University of California, Irvine
Biological Sciences
1979
Web Site Links
Research/Lab website:
Madison Lab Home Page
Research Interests
Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system. Most recently, we have been involved in studies of the intracellular messenger, nitric oxide. Nitric oxide appears to play a role both in inducing LTP and also in communicating LTP between groups of unconnected synapses, thus creating funcitonal domains of alterered synapses.
The other major focus of the lab is the study of the modulation and short term plasticity of inhibitory synaptic transmission in the hippocampus by different neurotransmitter systems. Projects under this focus include studies on the modulatory properties of norepinesphrine, acetylcholine and opiates on hippocampal inhibitory circuitry and transmitter release.
Studies in the lab are carried out using a full range of electrophysiological techniques including extracellular field potential recording, intracellular recording,whjole cell and single channel recording in hippocampal slices and cultured neurons.
The other major focus of the lab is the study of the modulation and short term plasticity of inhibitory synaptic transmission in the hippocampus by different neurotransmitter systems. Projects under this focus include studies on the modulatory properties of norepinesphrine, acetylcholine and opiates on hippocampal inhibitory circuitry and transmitter release.
Studies in the lab are carried out using a full range of electrophysiological techniques including extracellular field potential recording, intracellular recording,whjole cell and single channel recording in hippocampal slices and cultured neurons.
Community and International Work
- MBL Neurobiology Course, Woods Hole, MA More »
Publications
- Montgomery JM, Madison DV "Discrete synaptic states define a major mechanism of synapse plasticity." Trends Neurosci 2004; 27: 12: 744-50 More »
- Finley MF, Scheller RH, Madison DV "SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission." Neuropharmacology 2003; 45: 6: 857-62 More »
- Montgomery JM, Madison DV "State-dependent heterogeneity in synaptic depression between pyramidal cell pairs." Neuron 2002; 33: 5: 765-77 More »
- Finley MF, Patel SM, Madison DV, Scheller RH "The core membrane fusion complex governs the probability of synaptic vesicle fusion but not transmitter release kinetics." J Neurosci 2002; 22: 4: 1266-72 More »
- Montgomery JM, Pavlidis P, Madison DV "Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation." Neuron 2001; 29: 3: 691-701 More »
45 publications: view full list