Tony Wyss-Coray
Academic Appointments
Appointment
Organization
Associate Professor (Research)
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Honors & Awards
Title
Organization
Date(s)
Zenith Award
Alzheimer's Association
2005
Distinguished Scholar Award
The John Douglas French Alzheimer’s Foundation
2005
Editor
Journal of Neuroinflammation
2004
Medical and Scientific Advisory Council
Alzheimer's Association of Northern California & Northern Nevada
2004
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
M.S.
University of Bern, Switzerland
Microbiology
1989
Ph.D.
University of Bern, Switzerland
Immunology
1992
Web Site Links
Research/Lab website:
Lab Website
Research Interests
Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer’s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.
Publications
- Luo J, Ho PP, Buckwalter MS, Hsu T, Lee LY, Zhang H, Kim DK, Kim SJ, Gambhir SS, Steinman L, Wyss-Coray T "Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis." J Clin Invest 2007; 117: 11: 3306-3315 More »
- Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L, Quinn JF, Rabinovici GD, Robinson WH, Sabbagh MN, So YT, Sparks DL, Tabaton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T "Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins." Nat Med 2007; 13: 11: 1359-62 More »
- Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T "Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology." J Clin Invest 2006; 116: 11: 3060-3069 More »
- Wyss-Coray T, "Inflammation in Alzheimer disease: driving force, bystander or beneficial response?" Nat Med 2006; 12: 9: 1005-15 More »
- Chong AK, Satterwhite T, Pham HM, Costa MA, Luo J, Longaker MT, Wyss-Coray T, Chang J "Live imaging of Smad2/3 signaling in mouse skin wound healing." Wound Repair Regen 2007 Sep-Oct; 15: 5: 762-6 More »
64 publications: view full list