Thomas Quertermous, MD
Academic Appointments
- Professor, Medicine - Cardiovascular Medicine
Contact Information
- Academic
Offices
Personal Information Tel (650) 723-5013Administrative Contact Celest Landini Administrative Assistant Email Tel Work 650-723-5013
Professional Snapshot
Postdoctoral Advisees
David Charo , Yoko Kojima , Nicholas Leeper , Azad Raiesdana
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information
| Consulting: | Aviir, Incorporated , Via Pharmaceuticals |
| Equity: | Via Pharmaceuticals |
| Service on Board of Directors: | Aviir, Incorporated |
Scientific Focus
Current Research Interests
The Quertermous laboratory employs two basic approaches of study to better understand the genetic basis of atherosclerotic heart disease. One approach uses basic molecular biology methodology, primarily working with cellular and genetic mouse models, and is focused on the recently identified apelin-APJ pathway. A second approach employs the power of modern human genetics. Informative cohorts have been collected that allow investigation of risk factors such as hypertension and insulin resistance as well as coronary heart disease. Initial studies have employed the candidate gene approach, and more recently whole genome association studies, to identify allelic variation that is associated with risk factor and disease susceptibility.
Clinical Trials
Publications
- Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Am J Physiol Heart Circ Physiol. 2009; (5): H1329-35
- Admixture mapping of quantitative trait loci for blood lipids in African-Americans. Hum Mol Genet. 2009; (11): 2091-8
- Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia. J Atheroscler Thromb. 2009; (4): 327-38
- Insulin resistance independently predicts the progression of coronary artery calcification. Am Heart J. 2009; (5): 939-45
- Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Proc Natl Acad Sci U S A. 2009; (20): 8227-32
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