Thomas Quertermous, MD
Academic Appointments
- Professor, Medicine - Cardiovascular Medicine
Contact Information
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Academic Offices
Personal Information Tel (650) 723-5013Administrative Contact Celest Landini Administrative Assistant Email Tel Work 650-723-5013
Scientific Focus
Research Interests
The Quertermous laboratory employs two basic approaches of study to better understand the genetic basis of atherosclerotic heart disease. One approach uses basic molecular biology methodology, primarily working with cellular and genetic mouse models, and is focused on the recently identified apelin-APJ pathway. A second approach employs the power of modern human genetics. Informative cohorts have been collected that allow investigation of risk factors such as hypertension and insulin resistance as well as coronary heart disease. Initial studies have employed the candidate gene approach, and more recently whole genome association studies, to identify allelic variation that is associated with risk factor and disease susceptibility.
Publications
- Increased rate of hair regrowth in mice with constitutive overexpression of Del1. "J Surg Res" 2008 ; 1 73-80
- Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis. "Am J Physiol Heart Circ Physiol" 2008 ; 3 H1351-H1368
- Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. "Hum Genet" 2008 ; 4 399-408
- In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. "Am J Physiol Heart Circ Physiol" 2008 ; 1 H88-98
- A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. "Atherosclerosis" 2008 ; 1 136-44
