My lab addresses two distinct questions. That is, how can precise patterns of neuronal connections be genetically programmed during development, and how, once formed, can such circuits be used to mediate complex visual behaviors? Using the fruit fly visual system as a model, we employ genetic approaches to manipulate the functions of genes and neurons. From this, we infer specific developmental roles for particular molecules, and infer specific computational roles for individual neurons.
Publications
Choe KM,
Prakash S, Bright A, Clandinin TR
"Liprin-{alpha} is required for photoreceptor target selection in Drosophila."
Proc Natl Acad Sci U S A
2006;
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Katsov A,
Clandinin TR
"Insect vision: remembering the shape of things."
Curr Biol
2006;
16:
10:
R369-71
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Clandinin TR,
"Surprising twists to exocyst function."
Neuron
2005;
46:
2:
164-6
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Prakash S,
Caldwell JC, Eberl DF, Clandinin TR
"Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets."
Nat Neurosci
2005;
8:
4:
443-50
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Choe KM,
Clandinin TR
"Thinking about Visual Behavior; Learning about Photoreceptor Function."
Curr Top Dev Biol
2005;
69:
187-213
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