Theodore Jardetzky
Academic Appointments
- Professor, Structural Biology
- Member, Bio-X
- Member, Cancer Center
Contact Information
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Academic Offices
Personal Information Email Tel (650) 498-4179Administrative Contact Sean Dolan Administrative Assistant Email Tel Work (650) 721-4175
Professional Snapshot
Honors and Awards
- Fellow, American Academy of Microbiology (2008)
- NIH Merit Award, NIAID/NIH (2001-present)
- Research Scholar, Leukemia and Lymphoma Society (2001-2006)
- Investigator Award, Cancer Research Institute (1999-2003)
- Pew Scholar in the Biomedical Sciences, Pew Foundation (1996-2001)
Professional Education
| Ph.D.: | University of Basel, Swizterland, Biophysical Chemistry (1986) |
| B.S.: | Stanford University, Chemistry (1982) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Scientific Focus
Research Interests
The Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.
Publications
- Class III viral membrane fusion proteins. Curr Opin Struct Biol. 2009; (2): 189-96
- Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes. J Virol. 2009; (13): 6664-72
- Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion. J Virol. 2009; (15): 7678-89
- Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. J Mol Biol. 2009; (1): 176-90
- Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. Structure. 2009; (2): 223-33
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