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Suzanne PfefferAcademic Appointments
Appointment
Organization
Professor
Member
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Curriculum Vitae PDF
Honors & Awards
Title
Organization
Date(s)
President
American Society for Cell Biology
2003
Merit Award
National Institute of Diabetes and Digestive and Kidney Disorders
1999-2009
Fellow
American Association for the Advancement of Science
1992
Presidential Young Investigator Award
National Science Foundation
1988-1993
Administrative Appointments
Title
Organization
Start Year
End Year
Chair
Stanford University School of Medicine - Biochemistry
1998
2006
Associate Chairman
Stanford University School of Medicine-Biochemistry
1997
1998
Associate Professor
Stanford University School of Medicine - Biochemistry
1992
1998
Assistant Professor
Stanford University School of Medicine-Biochemistry
1986
1992
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
A.B.
U.C. Berkeley
Biochemistry
1977
Ph.D.
U.C. San Francisco
Biochemistry
1983
Postdoctoral
U.C. San Francisco
Biochemistry
1984
Postdoctoral
Stanford University
Cellular Biochemistry
1985
Postdoctoral Advisees
Maika Deffieu,
Maikke Ohlson
Research Interests
During intracellular transport, proteins destined for the plasma membrane, secretory vesicles and prelysosomes must be sorted from one another within the Golgi complex, and sent to their appropriate addresses. The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. We would like to understand how transport vesicles select their contents, bud off from an organelle, translocate through the cytoplasm to recognize their target, and then fuse with their target to deliver specific cargo molecules. We have established a cell free system that reconstitutes a specific intracellular transport step: transport of mannose 6-phosphate receptors from prelysosomes to the trans Golgi network (TGN). The reaction is ATP dependent, requires cytosolic transport factors, and efficient. We discovered a Ras-like GTPase, Rab9, is required for this process. We are now studying proteins responsible for the specific localization of Rab GTPases in human cells. We have also discovered a large set of proteins responsible for receptor recycling to the TGN, including a protein named TIP47 that works with Rab9 to help package mannose 6-phosphate receptors into transport vesicles, and a Golgi tether that is needed for vesicle docking.
Publications
- Burguete AS, Fenn TD, Brunger AT, Pfeffer SR "Rab and Arl GTPase Family Members Cooperate in the Localization of the Golgin GCC185." Cell 2008; 132: 2: 286-298 More »
- Ganley IG, Espinosa E, Pfeffer SR "A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells." J Cell Biol 2008; 180: 1: 159-72 More »
- Pfeffer SR, "Unsolved Mysteries in Membrane Traffic." Annu Rev Biochem 2007; More »
- Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS "TBC1D20 is a RAB1 GAP that mediates HCV replication." J Biol Chem 2007; More »
- Ganley IG, Pfeffer SR "Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells." J Biol Chem 2006; More »
67 publications: view full list
