Key Documents
Stephen J Smith
Academic Appointments
- Professor, Molecular & Cellular Physiology
- Member, Bio-X
- Member, Cancer Center
Education & Community
Postdoctoral Advisees
Web Site Links
Scientific Focus
Research Interests
Research in the Smith Laboratory addresses brain development and function. Special interests include dynamic and structural aspects of synaptogenesis, cell-cell adhesion and synaptic plasticity. The experimental approach uses sophisticated optical imaging techniques to study live neural cells in cultures, tissues and intact organisms. Recent projects have addressed the dynamics of dendrite growth and presynaptic vesicle pools in hippocampus, the effects of patterned electrical activity in developing tissues, and cytoskeletal rearrangements during cell-cell adhesion events.
Publications
- Integrated semiconductor optical sensors for cellular and neural imaging. "Appl Opt" 2007 ; 10 1881-9
- The classical complement cascade mediates CNS synapse elimination. "Cell" 2007 ; 6 1164-78
- Circuit reconstruction tools today. "Curr Opin Neurobiol" 2007 ; 5 601-8
- Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits. "Neuron" 2007 ; 1 25-36
- Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. "Mol Pharmacol" 2006 ; 2 467-76
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