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Stephen GalliAcademic Appointments
Appointment
Organization
Professor
Professor
Member
Member
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Administrative Appointments
Title
Organization
Start Year
End Year
Chair
Stanford University School of Medicine - Pathology
1999
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Postdoctoral Advisees
Ching-Cheng Chen,
Archana Iyer,
Jennifer Lilla,
Alys Peisley,
Chunyan Qu
Research Interests
Mast cells, which normally reside in the tissues, and basophils, which circulate in the blood, are major effector cells of asthma and other IgE-associated allergic disorders and immune responses to parasites. However, mast cells also have been implicated (as effector and/or immunoregulatory cells) in many other settings, including certain autoimmune or inflammatory disorders, innate immune responses to pathogens and resistance to exogenous and exogenous agents which can express significant toxicity; mast cells also may contribute importantly, in certain settings, to angiogenesis, the regulation of epithelial development and function and fibrosis and other examples of tissue remodeling.
The goals of Dr. Galli’s laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other discorders in which mast cell have been implicated.
The goals of Dr. Galli’s laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other discorders in which mast cell have been implicated.
Publications
- Galli SJ, Tsai M "Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasis." J Dermatol Sci 2008; 49: 1: 7-19 More »
- Kalesnikoff J, Rios EJ, Chen CC, Barbieri MA, Tsai M, Tam SY, Galli SJ "Roles of RabGEF1/Rabex-5 domains in regulating Fc{epsilon}RI surface expression and Fc{epsilon}RI- dependent responses in mast cells." Blood 2007; More »
- Nakae S, Lunderius C, Ho LH, Schäfer B, Tsai M, Galli SJ "TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice." J Allergy Clin Immunol 2007; 119: 3: 680-6 More »
- Metz M, Grimbaldeston MA, Nakae S, Piliponsky AM, Tsai M, Galli SJ "Mast cells in the promotion and limitation of chronic inflammation." Immunol Rev 2007; 217: 304-28 More »
- Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, Saito H, Galli SJ "TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells." Blood 2007; 110: 7: 2565-8 More »
37 publications: view full list
