Stephen Galli

Clinical Focus

• Pathology
• Pathology and Laboratory Medicine

Administrative Appointments

• Chair, Stanford University School of Medicine - Pathology (1999 - present)

Professional Education

Postdoctoral Advisees

Thomas Marichal,  Kaori Mukai,  Laurent Reber,  Riccardo Sibilano,  Philipp Starkl

Internet Links

• Galli Lab

Current Research Interests

Mast cells, which normally reside in the tissues, and basophils, which circulate in the blood, are major effector cells of asthma and other IgE-associated allergic disorders and immune responses to parasites. However, mast cells also have been implicated (as effector and/or immunoregulatory cells) in many other settings, including certain autoimmune or inflammatory disorders, innate immune responses to pathogens and resistance to exogenous and exogenous agents which can express significant toxicity; mast cells also may contribute importantly, in certain settings, to angiogenesis, the regulation of epithelial development and function and fibrosis and other examples of tissue remodeling.

The goals of Dr. Galli’s laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other disorders in which mast cell have been implicated.

Clinical Trials

• Understanding Allergies Recruiting

Publications

• Critical role of P1-Runx1 in mouse basophil development. Mukai K, Benbarak M, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, Galli SJ. Blood. 2012
• IgE and mast cells in allergic disease. Galli SJ, Tsai M. Nat Med. 2012; 18 (5): 693-704
• Modulation of mTOR Effector Phosphoproteins in Blood Basophils from Allergic Patients. Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. J Clin Immunol. 2012
• Antiinflammatory and immunosuppressive functions of mast cells. Kalesnikoff J, Galli SJ. Methods Mol Biol. 2011: 677 207-20
• Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Herzenberg LA, Nadeau KC. Int Arch Allergy Immunol. 2011; 154 (4): 318-27