Stanley N. Cohen, MD
Academic Appointments
- Professor, Genetics
- Member, Bio-X
- Member, Stanford Cancer Institute
- Professor, Medicine
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-5315 Tel (650) 723-5316Administrative Contact Roberta Peterson Administrative Associate Email Tel Work (650) 723-5316
Professional Overview
Administrative Appointments
- Kwoh-Ting Li Professor, School of Medicine (1993 - present)
- Professor of Genetics, School of Medicine (1977 - present)
- Professor of Medicine, School of Medicine (1975 - present)
Professional Education
| M.D.: | University of Pennsylvania, Medicine (1960) |
| B.S.: | Rutgers University, Biological Sciences (1956) |
Internet Links
Scientific Focus
Current Research Interests
Certain of our investigations are aimed at elucidating the signals that govern RNA decay. We use E. coli to investigate the mechanism of action of specific ribonucleases, related proteins, small non-coding RNAs, and to identify cellular events and proteins that regulate the actions of these molecules. We are also interested in the developmental aspects of RNA stability, and study mechanisms that lead to changes in decay during morphological and biochemical differentiation in the developmentally complex bacterial genus, Streptomyces.
Our lab has long been interested in the mechanisms that lead to the evolution and dissemination of antibiotic resistance, and currently, we continue to pursue these interests by investigating the biology underlying the ability of bacteria to adapt non-mutationally to antibiotic exposure and other environmental stresses.
Some members of our lab use gene inactivation methods plus phenotypic selection approaches to investigate processes that perturb the biology of mammalian cells. One of these inactivation methods, RHKO (random homozygous knockout), enables the identification of cellular genes whose function is exploited by pathogenic microbes. We investigate the effects of genetic variation in these host genes on host sensitivity to pathogens and toxins. A small bioinformatics team within our research group has developed and implemented a novel system of computer programs (Genetic Analysis By Rules Incorporating Expert Logic; GABRIEL) that uses expert knowledge and statistical algorithms used for analysis of genetic data.
A recent area of investigation is the study of mechanisms that selectively enable transcription through expanded trinucleotide repeats (TNCs) of mammalian genomes and the actions of aggregated proteins generated by such repeats. TNCs have a causal role in a variety of degenerative neurological diseases.
Publications
- Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012; (11): 4146-51
- Human genetic variation altering anthrax toxin sensitivity. Proc Natl Acad Sci U S A. 2012; (8): 2972-7
- Improved control of tuberculosis and activation of macrophages in mice lacking protein kinase R. PLoS One. 2012; (2): e30512
- Ribonuclease E modulation of the bacterial SOS response. PLoS One. 2012; (6): e38426
- Second-site suppression of RNase E essentiality by mutation of the deaD RNA helicase in Escherichia coli. J Bacteriol. 2012; (8): 1919-26
- Spt4 is selectively required for transcription of extended trinucleotide repeats. Cell. 2012; (4): 690-701
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