Sean P. David, M.D., D.Phil.
Key Documents
Contact Information
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Clinical Offices
Stanford Family Medicine 900 Blake Wilbur Drive Rm W3045 MC: 5765 Stanford, CA 94305 Tel Work (650) 723-6963 Fax (650) 498-7750Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 498-4687 Tel (650) 723-6963Alternate Contact Randy Fauver Research Assistant EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Family Medicine
- Family Practice
Administrative Appointments
- Clinical Associate Professor of Family & Community Medicine, Stanford University School of Medicine (2009 - present)
- Physician curator, PharmGKB (2010 - present)
- Clinical Associate Professor (secondary appointment), Stanford Prevention Research Center (2011 - present)
- Adjunct Associate Professor of Family Medicine, Brown Alpert Medical School (2009 - present)
- Director of Primary Care Genetics Laboratory & Translational Research Center, Memorial Hospital of Rhode Island/Brown Alpert Medical School (2002 - 2009)
Honors and Awards
- James C. Puffer, M.D./American Board of Family Medicine/Insitute of Medicine Anniversary Fellow, Institute of Medicine (2011 - 2013)
- Benjamin Meaker Visiting Professorship, University of Bristol (2010)
- Family Practice Scholar Award, Glaxo-Wellcome (1997)
- Deans Teaching Excellence Award, Brown Alpert Medical School (2001)
- Profiles in Competence Teaching Award, Brown Alpert Medical School (2002)
Professional Education
| Medical Education: | University of Washington School of Medicine WA (1995) |
| BS: | University of Washington, Zoology (1990) |
| SM: | Harvard School of Public Health, Health & Social Behavior (1999) |
| PhD Training: | University of Oxford, UK (2006) |
| Internship: | NH Dartmouth Family Practice Residency NH (1996) |
Community and International Work
Scientific Focus
Current Research Interests
My research encompasses a collaborative, transdisciplinary initiative to translate molecular insights to genomically-tailored and patient-centered personalized medicine. Investigations are focused on the integration of three translational streams of investigation. The first stream triangulates genome-wide association studies with preclinical research using functional neuroimaging and other modalities aimed at elucidating biobehavioural mechanisms nicotine dependence and smoking cessation. The second stream investigates moderating effects of genotype on health-related behavior and drug response (particularly in smoking cessation treatment) in multiple ancestral populations. The third stream investigates the efficacy of genomically-tailored drug and behavioural therapies in prospective first-in-human clinical trials and evidenced-based medicine and policy research (e.g., systematic review/meta-analyses, cost-effectiveness analyses, healthcare delivery systems & educating the primary care workforce).
Clinical Trials
- Behaviorally Enhanced Counseling on Nicotine Dependence (BEACON) Trial. Active, not recruiting
Publications
- Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. Drug Alcohol Depend. 2012; (1-3): 7-13
- Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers. J Hum Hypertens. 2012
- Dopamine D4 receptor gene variation moderates the efficacy of bupropion for smoking cessation. Pharmacogenomics J. 2012; (1): 86-92
- PharmGKB summary: very important pharmacogene information for cytochrome P-450, family 2, subfamily A, polypeptide 6. Pharmacogenet Genomics. 2012
- Smoking and genetic risk variation across populations of European, asian, and african american ancestry-a meta-analysis of chromosome 15q25. Genet Epidemiol. 2012; (4): 340-51
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