 |
|
|
Samuel StroberAcademic Appointments
Appointment
Organization
Professor
Member
|
Curriculum Vitae Doc
NIH Biosketch PDFPostdoctoral Advisees
David Hongo Apum,
Alexander Filatenkov,
Zhenyu Yao
Web Site Links
Research/Lab website:
Strober Lab
Research Interests
Our interests are in the area of cellular immunology, and the regulatory interactions between subpopulations of immune cells. In particular, we are interested in the identification, function, and molecular mechanisms by which some subpopulations of lymphocytes amplify the immune response and some suppress it. Investigation into interactions of the cells during the immune response to organ and bone marrow transplants and in autoimmune disease is a major focus of the laboratory research. Developing therapeutic strategies for organ transplantation and autoimmunity based on these principles is a major goal. Specific areas of research are as follows: (i) Immune tolerance to organ and bone marrow transplants: Immune tolerance is recognized to be the paralysis of the immune system in its response to a given antigen, the development of anergy, or antigen-specific suppressor cells. Our research programs are studying these mechanisms at the cellular and molecular levels in laboratory animals and humans that are made tolerant to foreign organ or bone marrow transplants. (ii) Mechanisms of autoimmunity: Many autoimmune diseases represent a breakdown of immune tolerance to self-antigens. The mechanisms by which 1) animals develop tolerance to self during ontogeny, 2) tolerance is broken in adult life resulting in autoimmune diseases, and 3) tolerance can be reestablished after the development of autoimmune disease are the subjects of investigation. Our laboratory is involved in identifying those cells involved in the induction and maintenance of immune tolerance with regard to their surface receptors, effector functions, and the nature of secreted molecules which mediate their function.
Publications
- Pillai AB, George TI, Dutt S, Teo P, Strober S "Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation." J Immunol 2007; 178: 10: 6242-51 More »
- Takahashi T, Dejbakhsh-Jones S, Strober S "Expression of CD161 (NKR-P1A) Defines Subsets of Human CD4 and CD8 T Cells with Different Functional Activities." J Immunol 2006; 176: 1: 211-6 More »
- Flores MG, Holm B, Larson MJ, Lau MK, Si MS, Lowsky R, Rousvoal G, Grumet FC, Strober S, Hoppe R, Reitz BA, Borie DC "A technique of bone marrow collection from vertebral bodies of cynomolgus macaques for transplant studies." J Surg Res 2005; 124: 2: 280-8 More »
- Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP, Negrin RS, Fathman CG, Strober S "Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD." Blood 2005; 105: 5: 2220-6 More »
- Lowsky R, Takahashi T, Liu YP, Dejbakhsh-Jones S, Grumet FC, Shizuru JA, Laport GG, Stockerl-Goldstein KE, Johnston LJ, Hoppe RT, Bloch DA, Blume KG, Negrin RS, Strober S "Protective conditioning for acute graft-versus-host disease." N Engl J Med 2005; 353: 13: 1321-31 More »
97 publications: view full list
