Samuel So

Clinical Focus

• Cancer> GI Oncology
• Liver Cancer
• Liver Cancer - Surgery
• Gastrointestinal Cancers - Surgical Oncology
• General Surgery

Administrative Appointments

• Special Adviser on Viral Hepatitis, World Health Organization Western Pacific Region (2011 - present)
• Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies (2006 - 2012)
• Committee on the Prevention and Control of Viral Hepatitis in the United States, Institute of Medicine of the National Academies (2008 - 2010)
• Roundtable on Health Disparity, Institute of Medicine of the National Academies (2008 - 2012)
• Conflict of Interest Committee, Stanford University School of Medicine (2008 - 2011)

Honors and Awards

• Outstanding Individual of the Year, Asian American Women Alliance, Santa Clara, California (2011)
• Honor Award for Excellence in Partnering in Global Health, CDC and ATSDR (2010)
• Excellence in Partnering Award-Domestic, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention (2010)
• Outstanding American by Choice Award, US Citizenship and Immigration Services (2010)
• Asian American Achievement Award, Organization of Chinese Americans, San Mateo, California (2010)

Professional Education

Postdoctoral Advisees

Wenjing Lu,  Kin Wai Sun,  Xiaolin Wang,  Xiaoyang Yang

Graduate & Fellowship Program Affiliations

• Surgery

Community and International Work

• Team HBV 
• Hep B Moms 
• Santa Clara Hepatitis B Free Campaign, Santa Clara 
• Asia and Pacific Alliance to Eliminate Viral Hepatitis, Asia 
• An evidence based hepatitis B online training course for healthcare workers in China, Shandong province, China 

Internet Links

• Asian Liver Center

Current Research Interests

Through a 3 pronged comprehensive program: translational and clinical research, early detection and treatment, and promoting education, awareness and immunization, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Our current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.

Clinical Trials

• Identification of New Serum Diagnostic Markers of Hepatocellular Carcinoma Recruiting
• Viral & Host Factors Associated with Hepatitis B Virus-related Hepatocelluar Carcinoma Recruiting
• PII Combination SBRT with TACE for Unresectable Hepatocellular Carcinoma Recruiting
• Perfusion CT as a Predictor of Treatment Response in Patients with Hepatic Malignancies Recruiting
• Genetic Analysis of Liver Cancer Terminated

Publications

• The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Willingham SB, Volkmer JP, Gentles AJ, Sahoo D, Dalerba P, Mitra SS, Wang J, Contreras-Trujillo H, Martin R, Cohen JD, Lovelace P, Scheeren FA, Chao MP, Weiskopf K, Tang C, Volkmer AK, Naik TJ, Storm TA, Mosley AR, Edris B, Schmid SM, Sun CK, Chua MS, Murillo O, Rajendran P, Cha AC, Chin RK, Kim D, Adorno M, Raveh T, Tseng D, Jaiswal S, Enger PO, Steinberg GK, Li G, So SK, Majeti R, Harsh GR, van de Rijn M, Teng NN, Sunwoo JB, Alizadeh AA, Clarke MF, Weissman IL. Proc Natl Acad Sci U S A. 2012
• A model program for hepatitis B vaccination and education of schoolchildren in rural China. Chen JJ, Chang ET, Chen YR, Bailey MB, So SK. Int J Public Health. 2011
• Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. Lin AY, Chua MS, Choi YL, Yeh W, Kim YH, Azzi R, Adams GA, Sainani K, van de Rijn M, So SK, Pollack JR. PLoS One. 2011; 6 (2): e16636
• Doing Good with Good OR: Supporting Cost-effective Hepatitis B Interventions. Hutton DW, Brandeau ML, So SK. Interfaces (Providence). 2011; 41 (3): 289-300
• In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. Darpolor MM, Yen YF, Chua MS, Xing L, Clarke-Katzenberg RH, Shi W, Mayer D, Josan S, Hurd RE, Pfefferbaum A, Senadheera L, So S, Hofmann LV, Glazer GM, Spielman DM. NMR Biomed. 2011; 24 (5): 506-13