Professional Snapshot
Honors and Awards
- Editor, Journal of Neuropathology and Experimental Neurology (2007-2009)
- Associate Editor, Journal of Neuropathology and Experimental Neurology (2005-)
Professional Education
| M.D.: | UCSF, Medicine (1976) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Research Interests
The lab is concerned with mechanisms of cellular immune reactions and tissue injury in the central nervous system (CNS) as they occur in human multiple sclerosis (MS. CNS tissue samples from animals with experimental autoimmune encephalomyelitis (EAE), a model of MS, and from patients with MS and other CNS diseases are studied using histology and immunohistochemistry at the light microscopic and ultrastructural levels to visualize directly the locations of molecules that are involved in immune-mediated injury and the failure of tissue repair.
We are currently focusing on alterations of extracellular matrix heparan sulfate proteoglycans (HSPGs) as their catabolic products may inhibit endogenous neuronal regeneration. We are also analyzing ephrins, cell surface molecules involved in development that are re-expressed in CNS injury, integrin receptors of extracellular matrix molecules and other adhesion molecules on lesions of EAE and MS. Cross-recognition of neurons and neuronal precursors by anti-myelin proteolipid protein antibodies may result in neuronal dysfunction and the failure of neuronal repair in CNS injury.
Publications
- Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci U S A. 2009; (35): 14948-53
- Comparative efficacies of lipid-complexed amphotericin B and liposomal amphotericin B against coccidioidal meningitis in rabbits. Antimicrob Agents Chemother. 2009; (5): 1858-62
- Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease. J Immunol. 2009; (10): 6717-23
- Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest. 2008; (1): 173-82
- Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med. 2007; (2): 321-30
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