Raymond A. Sobel, M.D.
Academic Appointments
- Professor, Pathology
- Professor (By courtesy), Neurology & Neurological Sciences
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 852-3279
Professional Overview
Honors and Awards
- Editor, Journal of Neuropathology and Experimental Neurology (2007-2012)
- Associate Editor, Journal of Neuropathology and Experimental Neurology (2005-)
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
The lab is concerned with mechanisms of cellular immune reactions and tissue injury in the central nervous system (CNS) as they occur in human multiple sclerosis (MS. CNS tissue samples from animals with experimental autoimmune encephalomyelitis (EAE), a model of MS, and from patients with MS and other CNS diseases are studied using histology and immunohistochemistry at the light microscopic and ultrastructural levels to visualize directly the locations of molecules that are involved in immune-mediated injury and the failure of tissue repair.
We are currently focusing on alterations of extracellular matrix heparan sulfate proteoglycans (HSPGs) as their catabolic products may inhibit endogenous neuronal regeneration. We are also analyzing ephrins, cell surface molecules involved in development that are re-expressed in CNS injury, integrin receptors of extracellular matrix molecules and other adhesion molecules on lesions of EAE and MS. Cross-recognition of neurons and neuronal precursors by anti-myelin proteolipid protein antibodies may result in neuronal dysfunction and the failure of neuronal repair in CNS injury.
Publications
- Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Sci Transl Med. 2013; (179): 179ra42
- A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells. J Immunol. 2012; (5): 2084-92
- Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neurons. J Virol. 2012; (1): 578-83
- Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med. 2012; (9): 1394-400
- Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis. J Biol Chem. 2012; (43): 36423-34
- Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012; (30): 12105-10
Help