Philip Beachy
Academic Appointments
- Professor, Developmental Biology
Contact Information
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Academic Offices
Personal Information EmailAdministrative Contact Administrative Assistant Email Tel Work 736-8530
Professional Snapshot
Administrative Appointments
- Member, Institute for Stem Cell Biology and Regenerative Medicine (2006 - present)
- Member, Stanford Cancer Center (2006 - present)
Honors and Awards
- March of Dimes Prize in Developmental Biology, March of Dimes Birth Defects Foundation (2008)
- Fellow, American Academy of Arts and Sciences (2003)
- Member, National Academy of Sciences (2002)
- National Academy of Sciences Award in Molecular Biology, National Academy of Sciences (1998)
- Outstanding Young Scientist Award, Maryland Academy of Sciences (1997)
Professional Education
| Ph.D.: | Stanford University, Biochemistry (1986) |
| B.S.: | Goshen College, Goshen, Indiana, Natural Sciences (1979) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Industry Relationships
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| Consulting: | Fate Therapeutics Inc |
Scientific Focus
Research Interests
My lab studies the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Publications
- Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc. Natl. Acad. Sci. U.S.A.. 2007: 4048-4053
- Prevalence of off-target effects in Drosophila RNA interference screens. Nature. 2006: 359-363
- Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc. Natl. Acad. Sci. U.S.A.. 2006: 17208-17213
- The ihog cell-surface proteins bind Hedgehog and mediate pathway activation Cell. 2006: 343-357
- Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice. Proc. Natl. Acad. Sci. U.S.A.. 2006: 1452-1456
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