Or Gozani
Academic Appointments
- Assistant Professor, Biology (School of Humanities and Sciences)
- Member, Cancer Center
Contact Information
- Academic
Offices
Personal Information EmailAdministrative Contact Shalien Izzi Administrative Associate Email Tel Work 650-724-1512
Professional Snapshot
Honors and Awards
- Searle Scholar, Searle Scholars Program (2007-2010)
- Terman Fellowship, Fredrick E. Terman Foundation (2006-2008)
- Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research (2006-2008)
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund (2003 - 2008)
- Mentored Clinical Scientist Development Award (KO8), NIA (2002 - 2007)
Professional Education
| M.D.: | Harvard Medical School, (1999) |
| Ph.D.: | Harvard Medical School, (1999) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
Publications
- ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol Cell. 2009; (2): 248-56
- RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature. 2007; (7172): 1106-10
- Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell. 2007; (4): 636-46
- ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006; (7098): 96-9
- NMR assignments and histone specificity of the ING2 PHD finger. Magn Reson Chem. 2009; (4): 352-8
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