Key Documents
Mylene W. M. Yao, M.D.
Academic Appointments
- Assistant Professor, Obstetrics & Gynecology
Contact Information
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Clinical Offices
900 Welch Rd, Ste 20 Palo Alto, CA 94304 Tel Work (650) 498-7408 Fax (650) 498-4320
- Academic Offices
Personal Information EmailAdministrative Contact Tracy Lindsay AA Email Tel Work 650.498.7408Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Fertility (Reproductive Medicine)
- Gynecology
- Reprod. Endocrinology and Infertility
Honors and Awards
- Organon Research Award, American Society for Reproductive Medicine (ASRM) (2003)
- Reproductive Scientist Development Program (RSDP) Research Award, American Society for Reproductive Medicine (ASRM)/NICHD (2002)
- Academic Training Fellowship Award in Ob/Gyn, American College of Obstetrics and Gynecology (ACOG)/Ortho-McNeil Pharmaceutical (2000)
Professional Education
| Board Certification: | Obstetrics and Gynecology, American Board of Obstetrics and Gynecology (2005) |
| Fellowship: | Brigham and Women's Hospital, Harvard Medical School, MA (2001) |
| Residency: | McGill University, Canada (1998) |
| Internship: | Royal Victoria Hospital, Canada (1994) |
| Medical Education: | University of Toronto, Canada (1993) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Industry Relationships
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| Consulting: | Fluidigm Corporation |
Scientific Focus
Current Research Interests
My laboratory is interested in early mammalian embryo development. We investigate genes and mechanisms that are critical in early embryo development using gene knockdown and other experimental systems that we have established for the mouse and human embryo. Specifically, we aim to understand how key processes such as nuclear reprogramming, establishment of developmental competence, maintenance of pluripotency, and cell cycle regulation are regulated at the earliest stages of mouse and human development.
We have taken innovative approaches to establish human and mouse models, both in vitro and in vivo, to identify the genetic and physical determinants that are critical and sufficient for optimal development. Our discoveries and methods have now enabled us to generate and test novel hypotheses and dissect the dynamic gene regulatory network in the early embryo. In addition, we are poised to investigate early human development in a translational context that is directly relevant to human health and disease.
Our research is relevant to the fields of stem cell, cancer, and assisted reproductive technologies. Errors that occur during early embryo development can lead to a wide spectrum of clinical conditions such as pregnancy loss, obstetrical complications, congenital defects, and infertility. Further, the fields of embryonic stem cell and reproductive medicine research face similar challenges, as exemplified by insufficient understanding of mechanisms that control reprogramming. Finally, the early mouse and human embryo remains a relatively untapped, yet extremely valuable model for cancer research, as many genes that are implicated in human cancers are also expressed at high levels in the early embryo.
Publications
- In vitro embryo culture in defined, sub-microliter volumes. Dev Dyn. 2009; (4): 950-5
- Gene expression profiles of human inner cell mass cells and embryonic stem cells. Differentiation. 2009; (1): 18-23
- A novel and critical role for Oct4 as a regulator of the maternal-embryonic transition. PLoS One. 2008; (12): e4109
- Defining human embryo phenotypes by cohort-specific prognostic factors. PLoS One. 2008; (7): e2562
- A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells. Cell Cycle. 2007; (18): 2276-83
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