Community Academic
Profiles |
|
 |
|
|
Minnie Sarwal
Academic Appointments
Appointment
Organization
Associate Professor - Med Center Line
Member
Graduate & Fellowship Program Affiliations
|
|
|
Honors & Awards
Title
Organization
Date(s)
Outreach Committee Core Member
International Pediatric Transplant Association
2007-9
Hospital Leadership
LPCH
2005-6
Key Opinion Leader
The Transplantation Society
2007
Councillor
International Pediatric Transplant Association
2006-10
Senator at Large
Faculty Senate, Stanford University
2006-9
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
Cambridge University
Molecular Genetics
1995
M.R.C.P.
Royal College of Physicians, UK
-
1990
D.C.H.
University of London, UK
Pediatrics
1989
M.B.B.S.
Calcutta Medical College
Surgery, Obstetrics/Gynecology
1985
I.S.C.
La Martiniere, Calcutta, India
-
1981
Research Interests
Translational research into the molecular and immunological basis of transplant dysfunction. Using competitive quantitaive RT-PCR and immunohistochemistry, granulysin was identified as a novel peripheral blood marker for transplant rejection, and its distribution in tissue defined steroid resistance or sensitivity. Prospective screening studies are underway to define this as a predictive assay for subclinical rejection.
cDNA Microarray analysis is being conducted on blood and tissue specimens in patients undergoing steroid based and a novel steroid free immunosuppression protocol (designed by Drs Sarwal and Salvatierra at Stanford). Samples are simultaeously hybridized to 23,000 human cDNA's (with about 40% of these cDNA's being unidentified novel genes) in collaboration with Dr. Pat Brown at Stanford.
New mecahnisms and genes are being identified for acute rejection, chronic rejection and drug nephrotoxicity. This information may allow for clearer differentiation between these varying causes of transplant dysfunction, without biopsy analysis and also offer means to individualizing immunotherapy for transplant patients.
Publications
-
Brouard S,
Mansfield E, Braud C, Li L, Giral M, Hsieh SC, Baeten D, Zhang M, Ashton-Chess J, Braudeau C, Hsieh F, Dupont A, Pallier A, Moreau A, Louis S, Ruiz C, Salvatierra O, Soulillou JP, Sarwal M
"Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance."
Proc Natl Acad Sci U S A
2007;
104:
39:
15448-53
More »
-
Sarwal MM,
Vidhun JR, Alexander SR, Satterwhite T, Millan M, Salvatierra O
"Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation."
Transplantation
2003;
76:
9:
1331-9
More »
-
Sarwal M,
Chua MS, Kambham N, Hsieh SC, Satterwhite T, Masek M, Salvatierra O
"Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling."
N Engl J Med
2003;
349:
2:
125-38
More »
-
Sutherland SM,
Hong DK, Balagtas J, Gutierrez K, Dvorak CC, Sarwal M
"Liposomal amphotericin B associated with severe hyperphosphatemia."
Pediatr Infect Dis J
2008;
27:
1:
77-9
More »
-
Li L,
Chaudhuri A, Weintraub LA, Hsieh F, Shah S, Alexander S, Salvatierra O, Sarwal MM
"Subclinical cytomegalovirus and Epstein-Barr virus viremia are associated with adverse outcomes in pediatric renal transplantation."
Pediatr Transplant
2007;
11:
2:
187-95
More »
|
NIH Biosketch Doc