Key Documents
Minnie Sarwal
Academic Appointments
- Professor - Med Center Line, Pediatrics - Nephrology
- Member, Bio-X
Contact Information
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Clinical Offices
Pediatric Nephrology Clinic 770 Welch Rd Ste 300 Palo Alto, CA 94304 Tel Work (650) 724-0353 Fax (650) 722-6685Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Administrative Contact Mary Hansen Administrative Associate Email Tel Work (650) 723-4517Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Nephrology (Kidney), Pediatric
- Pediatric Nephrology
Honors and Awards
- Outreach Committee Core Member, International Pediatric Transplant Association (2007-9)
- Hospital Leadership, LPCH (2005-6)
- Key Opinion Leader, The Transplantation Society (2006, 2007)
- Councillor, International Pediatric Transplant Association (2006-10)
- Senator at Large, Faculty Senate, Stanford University (2006-9)
Professional Education
| Fellowship: | University of Cambridge School of Clinical Medicine, England, UK (1995) |
| Residency: | Leicester Royal Infirmary, England (1990) |
| Residency: | Grantham & Kesteven Hospital, England (1989) |
| Internship: | Calcutta Medical College, India (1987) |
| Medical Education: | Calcutta Medical College, India (1987) |
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
Translational research into the molecular and immunological basis of transplant dysfunction. Using competitive quantitaive RT-PCR and immunohistochemistry, granulysin was identified as a novel peripheral blood marker for transplant rejection, and its distribution in tissue defined steroid resistance or sensitivity. Prospective screening studies are underway to define this as a predictive assay for subclinical rejection.
cDNA Microarray analysis is being conducted on blood and tissue specimens in patients undergoing steroid based and a novel steroid free immunosuppression protocol (designed by Drs Sarwal and Salvatierra at Stanford). Samples are simultaeously hybridized to 23,000 human cDNA's (with about 40% of these cDNA's being unidentified novel genes) in collaboration with Dr. Pat Brown at Stanford.
New mecahnisms and genes are being identified for acute rejection, chronic rejection and drug nephrotoxicity. This information may allow for clearer differentiation between these varying causes of transplant dysfunction, without biopsy analysis and also offer means to individualizing immunotherapy for transplant patients.
Clinical Trials
- Pediatric Study of Darbepoeitin Alfa weekly versus every two weeks to correct anemia in children with Chronic Kidney disease. Recruiting
- Efficacy study of Sriolimus, in place of Prograf, post-transplant to decrease kidney scarring and improveme kidney function and survival of the kidney. Not yet recruiting
- Rituximab for pediatric renal transplant rejection Completed
- Chronic Kidney Disease in Children Prospective Cohort Study (CKiD) Enrolling by Invitation
- Safety Efficacy of Iron Sucrose in Children No longer recruiting
Publications
- Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis. Pediatr Nephrol. 2009
- Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int. 2009
- C3 polymorphisms and outcomes of renal allografts. N Engl J Med. 2009; (23): 2478; author reply 2478-9
- Long-term outcome following pediatric liver transplantation for metabolic disorders. Pediatr Transplant. 2009
- Deconvoluting the 'omics for organ transplantation. Curr Opin Organ Transplant. 2009
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