Scientific Focus
Current Research Interests
The lesions of Parkinson's disease (PD) spread within the central nervous system (CNS) with characteristics of prion diseases. The prion in this case is a misfolded form of alpha-synuclein. We are investigating the mechanism of spread on alpha-synuclein prions with a special attention to axonal transport and transfer of prions between neurons. Understanding these pathways could lead to using drugs to slow down or halt disease progression.
Publications
- The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell. 2013; (4): 743-54
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport. Ann Neurol. 2012; (4): 517-24
- Multiple sclerosis and viruses. Ann Neurol. 2010; (1): 6-8
- Axon-myelin interactions during a viral infection of the central nervous system. PLoS Pathog. 2009; (9): e1000519
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