Merritt Maduke
Academic Appointments
- Assistant Professor, Molecular & Cellular Physiology
- Member, Bio-X
Professional Snapshot
Honors and Awards
- Cranefield Award, Society of General Physiologists (2008)
- Scientist Development Award, American Heart Association (2004-2007)
- Faculty Scholar, Esther Ehrman Lazard (2003-2005)
Education & Community
Professional Education
- Ph.D., UCSD, Chemistry & Biochemistry (1995)
- B.S., Wheaton College, Chemistry (1989)
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
CLC chloride-transport proteins are expressed ubiquitously. Defects in these proteins are responsible for human diseases of kidney and bone, for disorders of blood-pressure regulation, and for epilepsy.
Research in the Maduke lab involves a combination of electrophysiological, structural, and biochemical methods. In addition to ongoing projects, new directions include 1) using NMR to probe ion binding and conformational changes 2) designing and implementing high-throughput fluorescence-based assays to discover inhibitors and activators of the CLCs and 3) probing mechanisms of how mutations in ClC-2 lead to epilepsy.
Publications
- Thinking outside the crystal: Complementary approaches for examining transporter conformational change. "Channels (Austin)" 2008 ; 5
- Discovery of potent CLC chloride channel inhibitors. "ACS Chem Biol" 2008 ; 7 419-28
- The CLC 'chloride channel' family: revelations from prokaryotes. "Mol Membr Biol" 2007 Sep-Dec ; 5-6 342-50
- Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. "J Gen Physiol" 2005 ; 6 601-17
- Side-dependent inhibition of a prokaryotic ClC by DIDS. "Biophys J" 2005 ; 3 1721-30
Help