Maximilian Diehn, M.D., Ph.D.
Academic Appointments
- Acting Assistant Professor, Radiation Oncology - Radiation Therapy
Contact Information
- Academic
Offices
Personal Information Email
Professional Snapshot
Professional Education
| AB: | Harvard College, Biochemical Sciences (1997) |
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Scientific Focus
Research Interests
My lab focuses on cancer stem cell biology and its implications for cancer therapy. We are interested in developing a deeper molecular understanding of cancer stem cells, including identifying pathways and genes important for proliferation and self renewal. We also study these processes in normal adult stem cells in order to identify differences that could be exploited therapeutically. The goal of our studies is the development of novel therapeutic strategies for eliminating cancer stem cells.
Clinical Trials
Publications
- Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol. 2009; (2): 78-86
- Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009; (7239): 780-3
- Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 2009; (3): 592-603
- Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A. 2009; (33): 14016-21
- Identification of noninvasive imaging surrogates for brain tumor gene-expression modules. Proc Natl Acad Sci U S A. 2008; (13): 5213-8
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