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Matthew BogyoAcademic Appointments
Appointment
Organization
Assistant Professor
Assistant Professor
Assistant Professor (By courtesy)
Member
Member
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Curriculum Vitae PDF
NIH Biosketch DocHonors & Awards
Title
Organization
Date(s)
Investigator in Pathogenesis of Infectious Disease
Burroughs Wellcome
May 2005
Terman Fellow
Stanford University
2003
Searle Scholar
Searle Scholars Program
2004
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.S.
Bates College
Chemistry
1993
Ph.D.
MIT
Biochemistry
1997
Postdoctoral Advisees
Victoria Albrow,
Paul Bowyer,
Edgar Deu Sandoval,
Jiyoun Lee,
Margot Paulick,
Aimee Shen,
Zhimou Yang
Web Site Links
Research/Lab website:
Bogyo Lab Main Site
Research Interests
Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:
1) Design and synthesis of novel chemical probes for each of the primary protease families.
2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii.
3) Defining the specific functional roles of proteases during the process of tumorogenesis.
4) In vivo imaging of protease activity
1) Design and synthesis of novel chemical probes for each of the primary protease families.
2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii.
3) Defining the specific functional roles of proteases during the process of tumorogenesis.
4) In vivo imaging of protease activity
Publications
- Arastu-Kapur S, Ponder EL, FonoviÄ! UP, Yeoh S, Yuan F, FonoviÄ! M, Grainger M, Phillips CI, Powers JC, Bogyo M "Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum." Nat Chem Biol 2008; More »
- Sadaghiani AM, Verhelst SH, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA, Bogyo M "Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases." Chem Biol 2007; 14: 5: 499-511 More »
- Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M "Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes." Nat Chem Biol 2007; 3: 10: 668-77 More »
- Yuan F, Verhelst SH, Blum G, Coussens LM, Bogyo M "A Selective Activity-Based Probe for the Papain Family Cysteine Protease Dipeptidyl Peptidase I/Cathepsin C." J Am Chem Soc 2006; 128: 17: 5616-5617 More »
- Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M "Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes." Mol Cell 2006; 23: 4: 509-21 More »
71 publications: view full list
