Matthew Bogyo
Academic Appointments
- Professor, Pathology
- Member, Stanford Cancer Institute
- Member, Bio-X
- Professor, Microbiology & Immunology
- Professor (By courtesy), Chemical and Systems Biology
Key Documents
Contact Information
- Academic Offices
Personal Information Email
Professional Overview
Honors and Awards
- Investigator in Pathogenesis of Infectious Disease, Burroughs Wellcome (May 2005)
- Terman Fellow, Stanford University (2003)
- Searle Scholar, Searle Scholars Program (2004)
Postdoctoral Advisees
Brooke Anderson-White, Matthew Child, Ian Foe, Montserrat Morell Fernandez, Leslie Ofori, Kristina Oresic Bender, Ehud Segal, Nimali Withana, Junpeng Xiao, Wouter van der Linden
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:
1) Design and synthesis of novel chemical probes for each of the primary protease families.
2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii.
3) Defining the specific functional roles of proteases during the process of tumorogenesis.
4) In vivo imaging of protease activity
Publications
- New technologies and their impact on 'omics' research. Curr Opin Chem Biol. 2013; (1): 1-3
- A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages. Chem Biol. 2012; (5): 619-28
- An optimized activity-based probe for the study of caspase-6 activation. Chem Biol. 2012; (3): 340-52
- Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nat Chem Biol. 2012; (9): 745-7
- New approaches for dissecting protease functions to improve probe development and drug discovery. Nat Struct Mol Biol. 2012; (1): 9-16
- Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain. Bioorg Med Chem Lett. 2012; (3): 1340-3
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