Matthew Bogyo

Honors and Awards

• Investigator in Pathogenesis of Infectious Disease, Burroughs Wellcome (May 2005)
• Terman Fellow, Stanford University (2003)
• Searle Scholar, Searle Scholars Program (2004)

Professional Education

Postdoctoral Advisees

Brooke Anderson-White,  Matthew Child,  Edgar Deu Sandoval,  Montserrat Morell Fernandez,  Kristina Oresic Bender,  Ehud Segal,  Salahuddin Syed,  Martijn Verdoes,  Nimali Withana,  Junpeng Xiao,  Wouter van der Linden

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Microbiology and Immunology
• Chemical and Systems Biology

Internet Links

• Bogyo Lab Main Site

Current Research Interests

Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:

1) Design and synthesis of novel chemical probes for each of the primary protease families.

2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii.

3) Defining the specific functional roles of proteases during the process of tumorogenesis.

4) In vivo imaging of protease activity

Publications

• New approaches for dissecting protease functions to improve probe development and drug discovery. Deu E, Verdoes M, Bogyo M. Nat Struct Mol Biol. 2012; 19 (1): 9-16
• Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M. Proc Natl Acad Sci U S A. 2011; 108 (26): 10568-73
• Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Nat Struct Mol Biol. 2011; 18 (3): 364-71
• Development of activity-based probes for cathepsin X. Paulick MG, Bogyo M. ACS Chem Biol. 2011; 6 (6): 563-72
• Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M. Chem Biol. 2011; 18 (6): 722-32