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Key Documents

Martin S. Angst

Academic Appointments

  • Associate Professor - Med Center Line, Anesthesia

Contact Information

  • Clinical Offices
    Anesthesia 300 Pasteur Dr S276A MC 5117 Stanford, CA 94305
    Tel Work (650) 498-5109 Fax (650) 725-8052
    Schedule appointment
  • Academic Offices
    Personal Information
    Email
    Administrative Contact
    Jenny Hu Administrative Associate Tel Work (650) 723-9896
    Not for medical emergencies or patient use

Professional Snapshot

Clinical Focus

  • Anesthesia
  • Anesthesia for Liver Transplantation
  • Neuroanesthesia

Education & Community

Professional Education

  • Fellowship: SUMC - Graduate Medical Education, CA (1996)
  • Residency: University of Bern - Switzerland, Switzerland (1994)
  • Residency: Regionalspital Burgdorf, Switzerland (1990)
  • Board Certification: Anesthesia, European Board of Anesthesiologists
  • Medical Education: Berne University School of Medicine, Switzerland (1987)

Scientific Focus

Research Interests

Our human experimental pain research laboratory was launched in 1995. Initial research focused on using experimental pain models in phase I/II clinical trails testing for analgesic efficacy and profile of novel analgesic drug candidates (systemic a2-adrenergic agonists) and of established analgesic drugs delivered with aid of innovative technology (opioids and oral osmotic pump systems). A second early interest examined the mode and site of action after intrathecal or epidural administration of analgesic drugs (spinal versus supraspinal effects).

Today, our laboratory is active in three major research areas. With aid of various pain models mimicking acute pain, inflammatory pain, and pain due to amplified neuronal processing at the level of the spinal cord we study plastic changes within the central nervous system as a consequence of analgesic drug therapy (opioid induced pain hypersensitivity), develop a biomarker assay in humans (cytokines, growth factors, neuropeptides, prostaglandins) for early validation or rejection of novel anti-inflammatory and analgesic drug candidates, and search for genetic differences (single nucleotide polymorphisms) responsible for inter-individual variations in pain sensitivity and responsiveness to analgesic drugs. Besides the experimental pain models we use techniques such as micro-dialysis, laser-doppler imaging, and immunohistochemistry to find answers to our questions.

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