Key Documents
Manuel Amieva
Academic Appointments
- Assistant Professor, Pediatrics - Infectious Diseases
- Assistant Professor, Microbiology & Immunology
Contact Information
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Clinical Offices
Medicine Specialties Clinic 730 Welch Rd 2nd Floor Palo Alto, CA 94304 Tel Work (650) 736-7642 Fax (650) 725-8040Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Infectious Diseases, Pediatric
- Pediatric Infectious Disease
Professional Education
| Board Certification: | Pediatric Infectious Disease, (2005) |
| Fellowship: | Stanford University School of Medicine, CA (2004) |
| Board Certification: | Pediatrics, American Board of Pediatrics (2003) |
| Residency: | Stanford University School of Medicine, CA (1999) |
| Internship: | Stanford University School of Medicine, CA (1998) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
My laboratory studies the strategies pathogens utilize to colonize and subvert the epithelial barrier. We have focused on the epithelial junctions as a target for bacterial pathogens, since the cell-cell junctions serve as both a barrier to infection and also a major control site for epithelial function. In particular, we are interested in how the gastric pathogen Helicobater pylori may cause cancer by interfering with cell signaling at the epithelial junctions. We are also studying how various bacteria cross and invade the epithelium. For example, we recently found that Listeria monocytogenes targets a specialized subset of cell-cell junctions at the tip of the intestinal villi to find its receptor for invasion. We are interested in determining whether this mode of gastrointestinal invasion of the epithelium is also used by other gastrointestinal pathogens.
Publications
- The complete genome sequence of Helicobacter pylori strain G27. J Bacteriol. 2009; (1): 447-8
- Host-bacterial interactions in Helicobacter pylori infection. Gastroenterology. 2008; (1): 306-23
- Listeria monocytogenes invades the epithelial junctions at sites of cell extrusion. PLoS Pathog. 2006; (1): e3
- Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells. Proc Natl Acad Sci U S A. 2005; (45): 16339-44
- Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection? Cancer Epidemiol Biomarkers Prev. 2005; (8): 1859-64
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