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Lubert StryerAcademic Appointments
Appointment
Organization
Emeritus Faculty, Acad Council
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Research Interests
Our major interst in the molecular basis of signal transduction by retinal rod cells. These exquistely sensitive amplifiers can be triggered by a single photon. Furthermore, rods can adapt to 100,000-fold changes in background illumination. Their responses to stimuli are highly precise in amplitude and timing. The molecular assemblies mediating these processes are packaged in highly concentrated form in the outer segment, which can be readily isolated. We are exploring this gift of nature by biochemical, biophysical, molecular genetic and electrophysicological approaches to elucidate the molecular basis of visual excitation and adaption. Our curent research is focused on the feedback role of calcium ion in recovery and adaption. We have cloned and expressed recoverin and neurocalcin, two new calcium-sensors in the retina and brain. A related interest is the molecular mechanism of calcium spiking. We are exploring how cells generate and read calcium spikes.
Publications
- Cao Y, Oh BC, Stryer L "Cloning and localization of two multigene receptor families in goldfish olfactory epithelium." Proc Natl Acad Sci U S A 1998; 95: 20: 11987-92 More »
- Erickson MA, Lagnado L, Zozulya S, Neubert TA, Stryer L, Baylor DA "The effect of recombinant recoverin on the photoresponse of truncated rod photoreceptors." Proc Natl Acad Sci U S A 1998; 95: 11: 6474-9 More »
- Ames JB, Ishima R, Tanaka T, Gordon JI, Stryer L, Ikura M "Molecular mechanics of calcium-myristoyl switches." Nature 1997; 389: 6647: 198-202 More »
- Ames JB, Tanaka T, Stryer L, Ikura M "Portrait of a myristoyl switch protein." Curr Opin Struct Biol 1996; 6: 4: 432-8 More »
- Stryer L, "Vision: from photon to perception." Proc Natl Acad Sci U S A 1996; 93: 2: 557-9 More »
39 publications: view full list
