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Linda Boxer Info

Linda Boxer

Email:
Profile: http://med.stanford.edu/profiles/Linda_Boxer/
Academic Appointments
Appointment
Organization
Professor
Medicine - Hematology
Member
Bio-X
Member
Cancer Center
Clinical Specialties
Malignant Hematology: Leukemia, Multiple Myeloma  

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Graduate & Fellowship Program Affiliations
Cancer Biology ;
 
Administrative Appointments
Title
Organization
Start Year
End Year
Chief, Division of Hematology
Stanford University School of Medicine
2004
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
MD
Stanford University
Medicine
1981
PhD
Stanford University
Biophysics
1981
Web Site Links
Research/Lab website:   L. Boxer lab site
Research Interests

We are studying the transcriptional deregulation of several oncogenes in human hematologic malignancies.

Activation of c-myc in Burkitt's lymphoma: We are examining the transcriptional deregulation of the translocated c-myc gene and the silencing of the normal c-myc gene in Burkitt's lymphoma. We are looking at the c-myc promoter and regions of the immunoglobulin locus that are responsible for the deregulation of the translocated c-myc gene. Several model systems have been designed.

Activation of bcl-2 in hematologic malignancies: In lymphomas with the t(14;18) translocation, the bcl-2 gene is translocated to the immunoglobulin locus and expressed at high levels. We are studying the mechanism of activation at a molecular level in human lymphoma tissue. We have also developed a model system to determine which region of the immunoglobulin locus is responsible for the activation of the translocated bcl-2 gene.

Expression profiling in ALL: We are examining gene expression profiles in acute lymphoblastic leukemia in response to chemotherapeutic agents.

Publications
  • Hu HM, Kanda K, Zhang L, Boxer LM "Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer." Leukemia 2007; More »
  • Xiang H, Wang J, Boxer LM "The Role of the cAMP-Response Element in the Bcl-2 Promoter in the Regulation of Endogenous Bcl-2 Expression and Apoptosis in Murine B Cells." Mol Cell Biol 2006; More »
  • Kobayashi S, Lackey T, Huang Y, Bisping E, Pu WT, Boxer LM, Liang Q "Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo." FASEB J 2006; 20: 6: 800-2 More »
  • Duan H, Heckman CA, Boxer LM "The immunoglobulin heavy-chain gene 3' enhancers deregulate bcl-2 promoter usage in t(14;18) lymphoma cells." Oncogene 2006; More »
  • Duan H, Heckman CA, Boxer LM "Histone Deacetylase Inhibitors Down-Regulate bcl-2 Expression and Induce Apoptosis in t(14;18) Lymphomas." Mol Cell Biol 2005; 25: 5: 1608-19 More »
49 publications:   view full list