Lawrence Steinman

Clinical Focus

• Neurology
• Neurology, Pediatric
• Multiple Sclerosis, Myasthenia Gravis, Immune Disorders

Administrative Appointments

• Chairman, Interdepartmental Program in Immunology, Interdepartmental Program in Immunology, Stanford University (2002 - 2005)

Honors and Awards

• Friedrich Sasse Prize, Free Univ.of Berlin (1994)
• Sen. Jacob Javits Award, US Congress (1988-2002)
• John M. Dystel Prize, American Academy of Neurology and National MS Society (2004)

Professional Education

• Board Certification: Neurology, American Board of Psychiatry and Neurology (1984)
• Residency: SUMC - Graduate Medical Education, CA (1980)
• Fellowship: National Institute of Health, MD (1977)
• Fellowship: Weizmann Institute Of Science, Israel (1977)
• Residency: SUMC - Graduate Medical Education, CA (1974)

Postdoctoral Advisees

Robert Axtell, Brigit de Jong

Graduate & Fellowship Program Affiliations

• Immunology
• Neurosciences

Research Interests

Our laboratory is dedicated to understanding the pathogenesis of autoimmune diseases, particularly multiple sclerosis. We have developed several new therapies for autoimmunity, including some in Phase 2 clinical trials, as well as one approved drug, natalizumab. We have developed microarray technology for detecting autoantibodies to myelin proteins and lipids. We employ a diverse range of molecular and celluar approaches to trying to understand multiple sclerosis.

Publications

• Improved efficacy of a tolerizing DNA vaccine for reversal of hyperglycemia through enhancement of gene expression and localization to intracellular sites. Solvason N, Lou YP, Peters W, Evans E, Martinez J, Ramirez U, Ocampo A, Yun R, Ahmad S, Liu E, Yu L, Eisenbarth G, Leviten M, Steinman L, Garren H "J Immunol" 2008 ; 12 (181) : 8298-307
• Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L "Nature" 2008 ; 7182 (451) : 1076-81
• Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Hur EM, Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L "Nat Immunol" 2007 ; 1 (8) : 74-83
• Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L "J Exp Med" 2007 ; 2 (204) : 321-30
• Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Bar-Or A, Vollmer T, Antel J, Arnold DL, Bodner CA, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi FD, Utz PJ, Valone F, Weiner L, Steinman L, Garren H "Arch Neurol" 2007 ; 10 (64) : 1407-15