Katrin Chua
Academic Appointments
- Assistant Professor, Medicine - Endocrinology/Gerontology/Metab
- Member, Cancer Center
- Member, Bio-X
Contact Information
- Academic
Offices
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Professional Snapshot
Honors and Awards
- Ellison Medical Foundation New Scholar in Aging, Ellison Medical Foundation/AFAR (2008-2012)
- Paul Beeson Scholar in Aging Research, National Institute on Aging/American Federation for Aging Research (2006-)
- Pfizer Postdoctoral Fellow in Rheumatology/Immunology, Pfizer (2002-2005)
- Fellow of the Jane Coffin Childs Memorial Fund For Medical Research, Jane Coffin Childs Memorial Fund For Medical Research (2001-2002)
- Sackler Scholar in Psychobiology, Harvard University (1995-1996)
Professional Education
| Ph.D.: | Harvard Medical School, Neuroscience/Cell Biology (2001) |
| M.D.: | Harvard Medical School, Medicine (2001) |
| B.A.: | Harvard University, Biochemistry/Molecular Biology (1991) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
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Scientific Focus
Current Research Interests
Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
Publications
- FUNCTIONAL DISSECTION OF SIRT6: IDENTIFICATION OF DOMAINS THAT REGULATE HISTONE DEACETYLASE ACTIVITY AND CHROMATIN LOCALIZATION. Mech Ageing Dev. 2010
- SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009; (1): 62-74
- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair Aging. 2009: 109-121
- Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Cell Cycle. 2009; (16): 2664-6
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008; (7186): 492-6
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