 |
|
|
Katrin ChuaAcademic Appointments
Appointment
Organization
Assistant Professor
Member
Member
|
Honors & Awards
Title
Organization
Date(s)
Paul Beeson Scholar in Aging Research
National Institute on Aging/American Federation for Aging Research
2006-
Pfizer Postdoctoral Fellow in Rheumatology/Immunology
Pfizer
2002-2005
Fellow of the Jane Coffin Childs Memorial Fund For Medical Research
Jane Coffin Childs Memorial Fund For Medical Research
2001-2002
Sackler Scholar in Psychobiology
Harvard University
1995-1996
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
Harvard Medical School
Neuroscience/Cell Biology
2001
M.D.
Harvard Medical School
Medicine
2001
B.A.
Harvard University
Biochemistry/Molecular
Biology
1991
Postdoctoral Advisees
Tao Hong,
Ron McCord
Research Interests
Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
Publications
- Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, Chang HY, Bohr VA, Ried T, Gozani O, Chua KF "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." Nature 2008; 452: 7186: 492-6 More »
- Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW "Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6." Cell 2006; 124: 2: 315-29 More »
- Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." Nature 2006; More »
- Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW "Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress." Cell Metab 2005; 2: 1: 67-76 More »
- Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P "Mice lacking HDAC6 have hyperacetylated tubulin but are viable and develop normally." Mol Cell Biol 2008; More »
19 publications: view full list
