Karl Sylvester
Academic Appointments
- Associate Professor - Med Center Line, Surgery - Pediatric Surgery
- Member, Bio-X
- Member, Cancer Center
Contact Information
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Clinical Offices
Pediatric Surgery 780 Welch Rd Ste 206 MC 5733 Palo Alto, CA 94305-5733 Tel Work (650) 723-6439 Fax (650) 724-5577Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Administrative Contact Francciny Solano Administrative Assistant Email Tel Work 650 723-6439Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Pediatric Surgery
- Surgery, Pediatric
Professional Education
| Board Certification: | Pediatric Surgery, American Board of Surgery (2002) |
| Fellowship: | The Children's Hospital of Philadelphia, PA (1997) |
| Fellowship: | Yale - New Haven Hospital, CT (2001) |
| Board Certification: | General Surgery, American Board of Surgery (2000) |
| Residency: | University of Pennsylvania, PA (1999) |
Postdoctoral Advisees
Scientific Focus
Current Research Interests
Dr. Sylvester joined the faculty at Stanford as an Assistant Professor in the Department of Surgery and Division of Pediatric Surgery in 2001. As part of his academic appointment, Dr. Sylvester joined The Children’s Surgical Research Program. His interests are in the biology of mesenchymal stem cells (MSC) and their potential use in clinical cellular therapy or as biologics for use in tissue engineering. He is currently examining the similarities in both genotype and phenotype of MSC from both adipose tissue and bone marrow in numerous mouse models.
Dr. Sylvester has also developed an interest in the regenerative processes of the liver, from both a humoral and local stem cell response perspective. He has developed models of both acute and chronic liver injury and is currently exploring the developmental signals and cellular elements that are responsible for liver growth, regrowth and regeneration.
Dr. Sylvester has established NIH funding for his work in the laboratory, in addition he currently holds two competitive research fellowships. He is the recipient of an American College of Surgeons Faculty Research Fellowship, and an American Pediatric Surgical Association Foundation award. His laboratory includes several post-doctoral trainees who have each achieved competitive funding to support their mentored research projects.
Clinical Trials
Publications
- Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology. 2008; (2): 706-18
- Doxycycline sclerotherapy as primary treatment of head and neck lymphatic malformations in children. J Pediatr Surg. 2008; (3): 451-60
- Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. PLoS One. 2008; (6): e2493
- Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology. 2007; (5): 1579-91
- Repair and regeneration: opportunities for carcinogenesis from tissue stem cells. J Cell Mol Med. 2006 Apr-Jun; (2): 292-308
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