Karl Blume
Academic Appointments
- Professor Emeritus, Medicine - Blood & Marrow Transplantation
- Emeritus Faculty, Acad Council, Medicine - Blood & Marrow Transplantation
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-0831
Scientific Focus
Current Research Interests
Allogeneic and autologous bone marrow transplantation (experimental and clinical) as a treatment modality for leukemia, lymphoma, Hodgkin's disease, multiple myeloma, hereditary disorders, immune defects and selective solid tumors. Development of novel preparatory regimens to prevent the recurrence of the underlying malignancies. Studies for the prevention of acute and chronic graft-versus-host disease. Testing of new anti-viral agents to prevent or treat viral infections.
Molecular studies for the detection of minimal malignant disease. Manipulation of allogeneic donor marrow to reduce graft-versus-host disease and still preserve graft-versus-leukemia activity. Use of highly purified autologous human hematopoietic stem cells. Testing of novel cloned human hematopoietic growth factors. Peri-transplant idiotype vaccination for patients with B-cell lymphoma. Characterization and kinetics of tumor specific T-lymphocytes in recipients of autologous marrow grafts.
Clinical Trials
- Allogeneic Transplantation Using TL1 & ATG for Older Patients with Hematologic Malignancies Recruiting
- Autologous Followed by Non-myeloablative Allogeneic Transplantation for Non-Hodgkin's Lymphoma Recruiting
- NMDP Research Database for Allogeneic Unrelated Hematopoietic Stem Cell Transplantation Recruiting
- Research Sample Repository for Allogeneic Unrelated Hematopoietic Stem Cell Transplantation Recruiting
- TLI & ATG for Non-Myeloablative Allogeneic Transplantation for MDS and MPD Recruiting
Publications
- Five-year follow-up of patients with advanced chronic lymphocytic leukemia treated with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning. J Clin Oncol. 2008; (30): 4912-20
- Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen. Blood. 2008; (3): 903-9
- Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation for adult patients with myelodysplastic syndrome and myeloproliferative disorders. Biol Blood Marrow Transplant. 2008; (2): 246-55
- Altered sexual health and quality of life in women prior to hematopoietic cell transplantation. Eur J Oncol Nurs. 2007; (4): 298-308
- High-dose carmustine, etoposide, and cyclophosphamide followed by allogeneic hematopoietic cell transplantation for non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2006; (7): 703-11
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