Kari Nadeau, MD, PhD
Academic Appointments
- Associate Professor - Med Center Line, Pediatrics - Immunology and Allergy
- Member, Child Health Research Institute
- Associate Professor - Med Center Line (By courtesy), Otolaryngology (Head and Neck Surgery)
Key Documents
Contact Information
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Clinical Offices
Allergy & Immunology 730 Welch RD Stanford, CA 94305 Tel Work (650) 723-0290Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
Professional Overview
Clinical Focus
- Allergy and Immunology
- Pediatric Allergy/Immun
Administrative Appointments
- Associate Professor, Affiliate appointment in Otolaryngology (2011 - present)
- Associate Professor, Pediatrics (2011 - present)
- Faculty Member, Multidisciplinary Program in Immunology (2007 - present)
- Faculty Member, Stanford Institute of Immunity, Transplantation and Infectious Disease (2007 - present)
- Assistant Professor, Pediatrics (2007 - 2011)
- Assistant Professor, Affiliate appointment in Otolaryngology (2007 - 2011)
Honors and Awards
- Junior Faculty Award, Clinical Immunological Society (2010)
- National Junior Faculty Award, American Lung Association (2009)
- Fellow, American Academy of Asthma, Allergy and Immunology (2008-present)
- Speaker Award, La Entrada Inspirational Speaker Series (2007)
- National Junior Faculty Award, American Academy of Asthma, Allergy and Immunology (2007)
- Stanford Free Clinics Teaching Award, Stanford Medical School (June 2007)
Professional Education
| Fellowship: | Stanford University Medical Center CA (2006) |
| Residency: | Children's Hospital Boston MA (1997) |
| Residency: | Stanford University Medical Center CA (2004) |
| Internship: | Children's Hospital Boston MA (1996) |
| Medical Education: | Harvard Medical School MA (1995) |
| Board Certification: | Allergy and Immunology, American Board of Allergy and Immunology (2007) |
Graduate & Fellowship Program Affiliations
Community and International Work
- Volunteer Clinical Faculty, Menlo Park VA
Scientific Focus
Current Research Interests
The Nadeau Laboratory focuses on the mechanisms of immune dysfunction in primary immune disease (PID), allergy, and asthma. In recent years, allergic disorders have reached epidemic proportions in children and adults. Many studies have determined that the immune system of patients with allergies (also called atopy), such as asthma, atopic dermatitis, food allergies, allergic rhinitis, allergic conjunctivitis and other atopic disorders, is overactive and skewed toward a certain subtype of immune cell called the Th2 cell. So far, there is little understanding of how cells turn off this abnormal proliferation and activation of the Th2 cell.
The Nadeau Laboratory has found that a type of cell, called the natural regulatory T cells (nTreg), can decrease Th2 cell overactivation in allergies, thus leading to improvement or even reversal of the allergic condition. By understanding how these Treg cells work, we hope to discover new diagnostic and therapeutic ways to treat or prevent allergic conditions.
The Nadeau Laboratory maintains a database and sample/tissue bank of healthy controls and patients treated at LPCH/Stanford Medical Center with allergic disorders. The main focus of our laboratory is five-fold:
1. To determine the role of STAT5a and STAT5b in Treg development and function;
2. Since Tregs may respond to pollution, we are studying the effect of ambient air pollution on Tregs;
3. Since most allergic conditions start in childhood, we are examining the role of Th2 and Treg in different age groups with and without allergies;
4. Since the activity of Th2 and Treg is determined by their interactions with other cell types, such as epithelial cells and dendritic cells, we are studying their effects on Th2/Treg interactions; and
5. Since improvement of Treg function is associated with improvement of allergic conditions, we are designing new allergy treatments (for example, sublingual immunotherapy, small molecule chemokines) that enhance Treg function.
Publications
- Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. J Clin Immunol. 2013; (2): 397-406
- Markers of antigen presentation and activation on eosinophils and T cells in the esophageal tissue of patients with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013; (3): 257-62
- Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr; (2): 284-8
- Asthma discordance in twins is linked to epigenetic modifications of T cells. PLoS One. 2012; (11): e48796
- Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. J Allergy Clin Immunol. 2012; (1): 215-24.e7
- Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012; (3): 565-73
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