Judith Frydman
Academic Appointments
- Professor, Biology (School of Humanities and Sciences)
- Member, Bio-X
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
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Professional Overview
Postdoctoral Advisees
TaoTao Chen, Dan Gestaut, Lukasz Joachimiak, Christine Livingston, Sebastian Pechmann, Shuhei Taguwa, Wilhelmina Vonk, Felix Willmund
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Publications
- The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure. 2012
- Cellular strategies of protein quality control. Cold Spring Harb Perspect Biol. 2011; (8): a004374
- Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. PLoS Biol. 2011; (7): e1001100
- Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. Cell. 2011; (2): 240-52
- A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis. J Cell Biol. 2010; (1): 69-81
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