Judith Frydman
Academic Appointments
- Associate Professor, Biology (School of Humanities and Sciences)
- Member, Cancer Center
- Member, Bio-X
Contact Information
- Academic
Offices
Personal Information Tel (650) 725-7833
Scientific Focus
Research Interests
The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Publications
- The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation. Nat Struct Mol Biol. 2009
- Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies. Nat Struct Mol Biol. 2008; (12): 1255-62
- Misfolded proteins partition between two distinct quality control compartments. Nature. 2008; (7208): 1088-95
- Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol. 2008; (7): 746-53
- Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell. 2007; (1): 121-35
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