Judith Frydman
Academic Appointments
- Professor, Biology (School of Humanities and Sciences)
- Member, Bio-X
- Member, Stanford Cancer Institute
Key Documents
Professional Overview
Postdoctoral Advisees
Dennis Bua, Justin Chartron, TaoTao Chen, Dan Gestaut, Allison Kriel, Mohit Kumar, Christine Livingston, Sebastian Pechmann, Emily Sontag, Shuhei Taguwa, Wilhelmina Vonk
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
The long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
Publications
- Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding. Nat Struct Mol Biol. 2013; (2): 237-43
- Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A. 2013; (8): 3077-82
- Hsp90 inhibitors exhibit resistance-free antiviral activity against respiratory syncytial virus. PLoS One. 2013; (2): e56762
- Principles of cotranslational ubiquitination and quality control at the ribosome. Mol Cell. 2013; (3): 379-93
- The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell. 2013; (1-2): 196-209
- The ribosome as a hub for protein quality control. Mol Cell. 2013; (3): 411-21
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