Joshua Brody
Academic Appointments
- Instructor, Medicine - Oncology
Contact Information
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Clinical Offices
Oncology 875 Blake Wilbur Dr Clinic F Stanford, CA 94305-5826 Tel Work (650) 498-6000 Fax (650) 723-7622
Professional Snapshot
Clinical Focus
- Cancer
- Burkitt's Lymphoma
- Hodgkin's Disease - Medical Oncology
- Lymphoma
- Non-Hodgkin's Lymphoma
Honors and Awards
- Program Project Grant - SUMC Blood and Marrow Transplantation, NIH (3/07-3/12)
- Investigators Award in Clinical Translation of Gene Therapy for Cancer $1M (Co-Investigator), Alliance for Cancer Gene Therapy (12/07 - 12/11)
- Special Fellow in Clinical Research (SFCR), The Leukemia & Lymphoma Society (deferred)
- Clinical Investigator -- Career Development Award, Lymphoma Research Foundation (07/2007 - 06/2010)
Professional Education
| BA: | Harvard University, Molecular and Cellular Biology (1996) |
| MD: | SUNY Stony Brook Medical School, Medicine (2000) |
| Internship: | Yale - New Haven Hospital, CT (2001) |
| Board Certification: | Internal Medicine, American Board of Internal Medicine (2003) |
| Residency: | Yale - New Haven Hospital, CT (2003) |
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
Also see:
http://sarcomaca.asco.org/ASCO/Meetings/ASCO+Annual+Meeting/Past+Annual+Meetings/2008+Annual+Meeting/2008+ASCO+Daily+News/Categories/Award+Winners/Bradley+Stuart+Beller+Award+Winner+Breaks+through+Lymphoma+Vaccine+Barrier
http://www.lymphoma.org/atf/cf/%7B0363CDD6-51B5-427B-BE48-E6AF871ACEC9%7D/LYMPH_SUMMER07.PDF
for more information.
We have two ongoing clinical trials designed to use a patient's immune system to eliminate their own cancer. The first trial is currently accruing patients with low-grade B cell lymphomas and have superficially accessible disease. One such site is treated with low dose external beam radiation along with intra-tumoral injection of an immunostimulant called 'CpG'. This vaccination maneuver is intended to educate the immune system to target lymphoma cells throughout the body. We have seen extremely encouraging results and no serious side effects amongst the first groups of patients treated. These results were initially presented at ASCO 2008 and received "highest ranking abstract" for that year. We intend to treat approximately 25 more patients over then next 2 years.
Another trial will open shortly is of novel strategy called 'immunotransplant' which increases the power of cancer vaccines. This study is specifically for patients with newly diagnosed mantle cell lymphoma. We have recently published pre-clinical results of this approach in Blood,113;85-94, 2009. We hope to enroll 30 patients in this study over the next 3 years.
For more information on either of these studies, please contact our Clinical Research Coordinator at 650-725-4968.
Clinical Trials
- A Phase II Intratumoral Injection PF-3512676 plus Local Radiation in Low-Grade B-Cell Lymphomas Recruiting
- Phase I/II of a CpG-Activated Whole Cell Vaccine Followed by Autologous “Immunotransplant” for MCL Recruiting
- Phase I/II CPG 7909 + Local XRT in Recurrent Low-Grade Lymphomas No longer recruiting
Publications
- Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors. Blood. 2009; (1): 85-94
- A case of complete heart block reverting to normal sinus rhythm after treatment for cardiac invasive Burkitt's lymphoma. Ann Hematol. 2007; (9): 687-90
- Treatment of mantle cell lymphoma: current approach and future directions. Crit Rev Oncol Hematol. 2006; (3): 257-65
- DC-based cancer vaccines: lessons from clinical trials. Cytotherapy. 2004; (2): 122-7
- Using signaling pathways to overcome immune tolerance to tumors. Sci STKE. 2004; (241): pe28
