Joseph  C. Wu

Clinical Focus

• Cardiovascular Disease
• Congenital Heart Disease (Adult)
• Echocardiography

Administrative Appointments

• Editorial Board, Journal of Nuclear Cardiology (2009 - present)
• Editorial Board, JACC: Cardiovascular Imaging (2008 - present)
• Editorial Board, Circulation: Cardiovascular Imaging (2008 - present)
• Board Member, SNM Molecular Imaging Center of Excellence (2006 - 2009)

Honors and Awards

• Douglas P. Zipes Distinguished Young Scientist Award, American College of Cardiology (2009)
• NIH Director's New Innovator Award, National Institutes of Health (2008-2013)
• Baxter Faculty Scholar Award, Baxter Foundation (2008-2009)
• BWF Career Award for Medical Scientists, Burroughs Wellcome Foundation (2007-2012)
• ACCF/GE Career Award in Cardiovascular Imaging, American College of Cardiology/General Electrics (2006-2008)

Professional Education

• Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2004)
• Fellowship: UCLA Medical Center, CA (2004)
• Board Certification: Internal Medicine, American Board of Internal Medicine (2000)
• Residency: UCLA Medical Center, CA (1999)
• Medical Education: Yale University School of Medicine-Graduate, CT (1997)

Postdoctoral Advisees

Zhumur Ghosh, Shijun Hu, Zongjin Li, Ning Sun

Web Site Links

• Wu Lab

Research Interests

My lab works on biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging technologies to better understand stem cell biology in vitro and in vivo. For adult stem cells, we are interested in monitoring stem cell survival, proliferation, and differentiation. For ESC, we are currently studying their tumorigenicity, immunogenicity, and differentiation. For iPSC, we are working on novel derivation techniques. We also work on development of novel vectors and therapeutic genes for cardiovascular gene therapy applications.

Publications

• MicroRNA profiling of human-induced pluripotent stem cells. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC "Stem Cells Dev" 2009 ; 5 (18) : 749-58
• Short hairpin RNA interference therapy for ischemic heart disease. Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC "Circulation" 2008 ; 14 Suppl (118) : S226-33
• Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Chen IY, Greve JM, Gheysens O, Willmann JK, Rodriguez-Porcel M, Chu P, Sheikh AY, Faranesh AZ, Paulmurugan R, Yang PC, Wu JC, Gambhir SS "Mol Imaging Biol" 2009 May-Jun ; 3 (11) : 178-87
• Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC "Transplantation" 2009 ; 5 (87) : 642-52
• Trafficking Mesenchymal Stem Cell Engraftment and Differentiation in Tumor-Bearing Mice by Bioluminescence Imaging. Wang H, Cao F, De A, Cao Y, Contag C, Gambhir SS, Wu JC, Chen X "Stem Cells" 2009