Joseph (Jody) Puglisi

Administrative Appointments

• Chair, University Committee on Postdoctoral Affairs, Stanford University (2008 - 2009)
• Chair, Provost's Advisory Board for Postdoctoral Affairs, Stanford University (2005 - 2008)
• Chair, Dept of Structural Biology, Stanford University School of Medicine (2004 - present)
• Director, Int'l School of Biological Magnetic Resonance, EMFCSC, Erice, Italy (2003 - present)
• Senior Editor, Structure (2003 - 2007)
View All 10administrative appointments of Joseph Puglisi

Honors and Awards

• Alfred P. Sloan Research Fellow, Alfred P. Sloan Research Foundation (1997)
• David and Lucille Packard Fellow, David and Lucille Packard Fellowship in Science and Engineering (1994-99)
• Teacher Scholar, Camille and Henry Dreyfus Teacher Scholar Award (1993)

Professional Education

Postdoctoral Advisees

Alexey Nikolayevich Petrov , Sotaro Uemura , Tinghe Wu

Graduate & Fellowship Program Affiliations

• Biophysics
• Microbiology and Immunology
• Chemical and Systems Biology
• Structural Biology
• Bioengineering

Community & International Work

• NMR Summer School, Erice-Sicily, Italy 

Web Site Links

• Puglisi Lab Homepage

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. View Full Information

Current Research Interests

The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.

Publications

• Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK. Nature. 2010; 463 (7277): 108-12
• Resolving the elegant architecture of the ribosome. Puglisi JD, Mol Cell. 2009; 36 (5): 720-3
• Translational insensitivity to potent activation of PKR by HCV IRES RNA. Shimoike T, McKenna SA, Lindhout DA, Puglisi JD. Antiviral Res. 2009; 83 (3): 228-37
• GTP hydrolysis by IF2 guides progression of the ribosome into elongation. Marshall RA, Aitken CE, Puglisi JD. Mol Cell. 2009; 35 (1): 37-47
• The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Elazar M, Liu M, McKenna SA, Liu P, Gehrig EA, Puglisi JD, Rossignol JF, Glenn JS. Gastroenterology. 2009; 137 (5): 1827-35