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Jennifer L. RaymondAcademic Appointments
Appointment
Organization
Associate Professor
Member
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Honors & Awards
Title
Organization
Date(s)
EJLB Foundation Scholar
EJLB Foundation
2004
Terman Fellow
Stanford University
1999
Klingenstein Fellow
Klingenstein Foundation
1999
McKnight Scholar
McKnight Endowment Fund for Neuroscience
1999
Sloan Fellow
Alfred P. Sloan Foundation
1999
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
U Texas, Houston
Neuroscience
1993
B.A.
Williams College
Mathematics
1987
Postdoctoral Advisees
Soon-Lim Shin,
Grace Zhao
Research Interests
My laboratory studies the neural mechanisms of learning. Our research aims to develop an integrated understanding of this fundamental brain function by systematically tracing learning from a sensory experience, through the neural encoding of that experience, to the induction of plasticity at specific loci in the brain, and the ultimate readout of the memory in an altered behavior. Toward this goal, we use a combination of behavioral, neurophysiological and computational approaches.
The model system we study is a form of learning that calibrates the amplitude of eye movements produced by the vestibuloocular reflex (VOR). As an experimental system, learning in the VOR offers many advantages: the neural circuitry mediating the behavior is well understood, putative sites of synaptic plasticity have been identified, and a key neural structure is the cerebellum, which is well suited for both in vivo and in vitro studies of the mechanisms of learning.
One current focus in the lab is to record from the cerebellum in awake behaving animals during the induction of learning in order to identify the neural "error signals" that detect a miscalibration in the VOR and trigger the neural changes underlying learning. Another current project is to study learning in the VOR of transgenic mice, as a tool for linking systems level analysis of learning with cellular and molecular analyses of synaptic plasticity.
The model system we study is a form of learning that calibrates the amplitude of eye movements produced by the vestibuloocular reflex (VOR). As an experimental system, learning in the VOR offers many advantages: the neural circuitry mediating the behavior is well understood, putative sites of synaptic plasticity have been identified, and a key neural structure is the cerebellum, which is well suited for both in vivo and in vitro studies of the mechanisms of learning.
One current focus in the lab is to record from the cerebellum in awake behaving animals during the induction of learning in order to identify the neural "error signals" that detect a miscalibration in the VOR and trigger the neural changes underlying learning. Another current project is to study learning in the VOR of transgenic mice, as a tool for linking systems level analysis of learning with cellular and molecular analyses of synaptic plasticity.
Publications
- Kimpo RR, Raymond JL "Impaired motor learning in the vestibulo-ocular reflex in mice with multiple climbing fiber input to cerebellar Purkinje cells." J Neurosci 2007; 27: 21: 5672-82 More »
- Boyden ES, Katoh A, Pyle JL, Chatila TA, Tsien RW, Raymond JL "Selective engagement of plasticity mechanisms for motor memory storage." Neuron 2006; 51: 6: 823-34 More »
- Katoh A, Jindal JA, Raymond JL "Motor deficits in homozygous and heterozygous P/Q-type calcium channel mutants." J Neurophysiol 2006; More »
- Kimpo RR, Boyden ES, Katoh A, Ke MC, Raymond JL "Distinct patterns of stimulus generalization of increases and decreases in VOR gain." J Neurophysiol 2005; 94: 5: 3092-100 More »
- Cohen MR, Meissner GW, Schafer RJ, Raymond JL "Reversal of motor learning in the vestibulo-ocular reflex in the absence of visual input." Learn Mem 2004 Sep-Oct; 11: 5: 559-65 More »
12 publications: view full list
