Jeffrey A. Feinstein, MD, MPH

Clinical Focus

• Pediatric Cardiology
• Congenital Heart Defects
• Pulmonary Hypertension
• Pulmonary Vascular Disease
• Pulmonary Vascular Abnormalities

Administrative Appointments

• Director, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University Medical Center (2000 - present)
• Associate Director, Pediatric and Congenital Cardiac Catheterization, Stanford University Medical Center (2001 - present)

Professional Education

• Board Certification: Pediatric Cardiology, American Board of Pediatric Cardiology (1998)
• Residency: Children's Hospital National Medical Center, DC (1994)
• Fellowship: Children's Hospital National Medical Center, DC (1997)
• Fellowship: Children's Hospital of Boston, MA (1998)
• MS, Duke University, Biomedical Engineering (1987)

Graduate & Fellowship Program Affiliations

• Pediatrics
• Bioengineering

Research Interests

Research interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) development and testing of transcatheter therapies for the treatment of congenital heart disease, and (3) the evaluation and treatment of pulmonary hypertension/pulmonary vascular disease.

In the area of computational modeling, projects are underway in three areas: (1) examination of alterations in blood flow and vessel mechanics caused by coarctation (narrowing) of the aorta and the use of computational modeling to compare surgical and transcatheter methods of treatment, (2) creation of a computational model of the entire pulmonary vascular tree and computational modeling of various disease states including pulmonary artery stenosis and pulmonary hypertension as a disease stratification tool and better predict responses to therapy, and (3) the use of computational modeling to examine flow characteristics and energy efficiency at rest and varying degrees of exercise in patients who have undergone total cavopulmonary connection.

Dr. Feinstein serves as the local P.I. for two ongoing multi-center clinical trials, one investigating a new oral therapy for the treatment of pediatric pulmonary hypertension and another comparing surgical treatment with balloon angioplasty or stent placement for treatment of coarctation of the aorta. Three additional clinical trials for which Dr. Feinstein will be the local P.I. are scheduled to begin within the next year.

Publications

• Effects of exercise and respiration on hemodynamic efficiency in CFD simulations of the total cavopulmonary connection. Marsden AL, Vignon-Clementel IE, Chan FP, Feinstein JA, Taylor CA "Ann Biomed Eng" 2007 ; 2 (35) : 250-63
• Percutaneous pulmonary valve placement in a 10-month-old patient using a hand crafted stent-mounted porcine valve. Feinstein JA, Kim N, Reddy VM, Perry SB "Catheter Cardiovasc Interv" 2006 ; 4 (67) : 644-9
• Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: the effects of exercise and age. Cheng CP, Herfkens RJ, Taylor CA, Feinstein JA "J Magn Reson Imaging" 2005 ; 6 (21) : 752-8
• Blood flow conditions in the proximal pulmonary arteries and vena cavae: healthy children during upright cycling exercise. Cheng CP, Herfkens RJ, Lightner AL, Taylor CA, Feinstein JA "Am J Physiol Heart Circ Physiol" 2004 ; 2 (287) : H921-6
• Morphometry-based impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries. Spilker RL, Feinstein JA, Parker DW, Reddy VM, Taylor CA "Ann Biomed Eng" 2007 ; 4 (35) : 546-59