Jan Carette
Academic Appointments
- Assistant Professor, Microbiology & Immunology
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-4468
Professional Overview
Internet Links
Scientific Focus
Current Research Interests
Our research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it might also facilitate the development of new therapeutic strategies.
Publications
- A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin. Proc Natl Acad Sci U S A. 2011; (29): 11756-65
- Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011; (7364): 340-3
- Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat Biotechnol. 2011; (6): 542-6
- Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT). Proc Natl Acad Sci U S A. 2011; (39): 16422-7
- Haploid genetic screens in human cells identify host factors used by pathogens. Science. 2009; (5957): 1231-5
- Generation of iPSCs from cultured human malignant cells. Blood. 2010; (20): 4039-42
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