James Trudell
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-5839
Professional Overview
Professional Education
| PhD: | Stanford University, Chemistry (1969) |
| B.S.: | University of Michigan, Chemistry (1963) |
Scientific Focus
Current Research Interests
I use computational chemistry to develop molecular theories of anesthesia and alcohol intoxication. I collaborate with three groups that use molecular biology to make site-directed mutations in ligand-gated ion channels. Molecular modeling of these channels is used to visualize the effect of mutations and to predict new mutations that will further refine their structure. I also use quantum mechanics calculations to determine the kinds of interactions that are likely to provide binding energy for anesthetic molecules at their sites of action.
Publications
- Teaching an Old GABA Receptor New Tricks. Anesth Analg. 2012
- Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcohol Clin Exp Res. 2011; (9): 1561-73
- Modeling anesthetic binding sites within the glycine alpha one receptor based on prokaryotic ion channel templates: the problem with TM4. J Chem Inf Model. 2010; (12): 2248-55
- Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. J Chem Inf Model. 2008; (4): 855-60
- Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model. 2008; (2): 344-9
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