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James TrudellAcademic Appointments
Appointment
Organization
Professor
Member
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Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
PhD
Stanford University
Chemistry
1969
B.S.
University of Michigan
Chemistry
1963
Research Interests
I use computational chemistry to develop molecular theories of anesthesia and alcohol intoxication. I collaborate with three groups that use molecular biology to make site-directed mutations in ligand-gated ion channels. Molecular modeling of these channels is used to visualize the effect of mutations and to predict new mutations that will further refine their structure. I also use quantum mechanics calculations to determine the kinds of interactions that are likely to provide binding energy for anesthetic molecules at their sites of action.
Publications
- Arias HR, Bhumireddy P, Spitzmaul G, Trudell JR, Bouzat C "Molecular Mechanisms and Binding Site Location for the Noncompetitive Antagonist Crystal Violet on Nicotinic Acetylcholine Receptors." Biochemistry 2006; 45: 7: 2014-2026 More »
- Bertaccini EJ, Shapiro J, Brutlag DL, Trudell JR "Homology modeling of a human glycine alpha 1 receptor reveals a plausible anesthetic binding site." J Chem Inf Model 2005 Jan-Feb; 45: 1: 128-35 More »
- Bertaccini EJ, Shapiro J, Brutlag DL, Trudell JR "Homology Modeling of a Human Glycine Alpha 1 Receptor Reveals a Plausible Anesthetic Binding Site" J Chem Inf Model 2005; Jan-Feb 45: 1: 128-35 More »
- Trudell JR, Bertaccini E "Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates." J Mol Graph Model 2004; 23: 1: 39-49 More »
- Kash, T.L., Dizon, M.J., Trudell, J.R., Harrison, N.L. "Charges residues in the beta2 subunit involved in GABAA receptor activation." J. Biol. Chem. 2004; 279: 4887-4893 More »
56 publications: view full list
