James D. Brooks

Clinical Focus

• Cancer> Urologic Oncology
• Male Cancers - Prostate
• Prostate Cancer
• Nerve-sparing radical prostatectomy
• Prostate Cancer - Urologic Oncology

Administrative Appointments

• Keith and Jan Hurlbut Professor, Stanford University (2012 - present)
• Acting Chair, Department of Urology (2012 - present)
• Associate Chair, Prostate Cancer Working Group EDRN (2010 - present)
• Editor-in-Chief, The Open Prostate Cancer Journal (2008 - present)
• Editorial Board, Andrology (2011 - present)

Honors and Awards

• Listing in Guide to America's Top Surgeons, Consumers' Research Council (2010)
• Best Doctors in America, Best Doctors Inc. (2004-2012)
• Leutje-Stubbs Faculty Scholar, Stanford University School of Medicine (2002-2003)
• Eugene P. Schonfeld Medical Research Award, Kidney Cancer Association (2000-2002)
• Clinician Scientist Award, Doris Duke Foundation (1998-2002)

Professional Education

Postdoctoral Advisees

Catherine Gordon,  Catherine Gordon

Graduate & Fellowship Program Affiliations

• Cancer Biology
• Urology

Current Research Interests

Our interest is in developing diagnostic and prognostic markers for urological diseases. We have approached this question broadly. We are active in biomarker discovery using genomic approaches. While our primary focus has been in prostate cancer, we have also worked in kidney bladder and testicular cancer. We are also actively seeking markers that reflect renal damage in patients with urinary obstruction. We are also interested in developing platforms for translating biomarkers discovered in the laboratory into clinical practice. For instance, we have active collaborations in developing novel molecular imaging strategies for prostate cancer. We also participate in several large clinical trials for development, validation and implementation of clinical biomarkers in prostate cancer.

Clinical Trials

• Microarray Analysis of Gene Expression in Prostate Tissues Recruiting
• Prostate Active Surveillance Study (PASS) Recruiting
• Quality of Life Following Radical Prostatectomy Recruiting
• Hypofractionated Radiotherapy for Localized Prostate Cancer (with CyberKnife or with IMRT) Completed
• Photoacoustic imaging (PAI) of the prostate: A clinical feasibility study Not yet recruiting

Publications

• Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability. Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC, Brown JM. Cancer Res. 2012
• Evaluation of Putative Renal Cell Carcinoma Markers PAX-2, PAX-8, and hKIM-1 in Germ Cell Tumors: A Tissue Microarray Study of 100 Cases. Sangoi AR, McKenney JK, Brooks JD, Bonventre JV, Higgins JP. Appl Immunohistochem Mol Morphol. 2012
• Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1. Gulzar ZG, McKenney JK, Brooks JD. Oncogene. 2012
• Long-term outcomes from a prospective trial of stereotactic body radiotherapy for low-risk prostate cancer. King CR, Brooks JD, Gill H, Presti JC. Int J Radiat Oncol Biol Phys. 2012; 82 (2): 877-82
• Methods for registration of magnetic resonance images of ex vivo prostate specimens with histology. Kimm SY, Tarin TV, Lee JH, Hu B, Jensen K, Nishimura D, Brooks JD. J Magn Reson Imaging. 2012