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Honors & Awards
Title
Organization
Date(s)
 Dornier Research Scholar
American Foundation for Urologic Disease
1995-1997
Clinician Scientist Award
Doris Duke Foundation
1998-2002
Eugene P. Schonfeld Medical Research Award
Kidney Cancer Association
2000-2002
Leutje-Stubbs Faculty Scholar
Stanford University School of Medicine
2002-2003
Administrative Appointments
Title
Organization
Start Year
End Year
Membership Committee
Society for Basic Urologic Research
2004
-
Editorial Board
The Prostate
2000
-
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
A. B.
University of Chicago
Biology
1982
M. D.
Stanford University
Medicine
1988
Research Interests
We have identified a genetic change common to all human prostate cancer - loss of expression of glutathione S-transferase-pi (GSTP1). Loss of expression is associated with extensive hypermethylation of deoxycytidine residues in 5'-regulatory sequences. Since GSTP1 is involved in defense against carcinogens, we are exploring induction of other carcinogen defense enzymes as a potential prostate cancer prevention strategy. Recently, we have identified several candidate phase 2 enzyme inducing agents that are effective in the prostate. We have used comprehensive gene expression profiling (DNA microarrays) to identify the mechanisms of action of some of these agents, and of other candidate prostate cancer preventive compounds. We have also used gene expression profiling to investigate the transciptional and DNA copy-number changes that occur in prostate and kidney cancer. We are using these large datasets to identify novel diagnostic and prognostic markers for these diseases. We have ongoing projects that correlate gene expression changes with the clinical features of the cancers.
Publications
89 publications: view full list
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