Isabella Graef
Contact Information
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Academic Offices
Personal Information EmailAdministrative Contact Patty Winningham Administrative Associate Email
Professional Snapshot
Postdoctoral Advisees
Ah Ryon Cho, Suhua Deng, Alexandra Esteras Chopo, Lining Liu, Yitai Tang
Graduate & Fellowship Program Affiliations
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Scientific Focus
Research Interests
We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches.
The main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with pathogenic protein-protein interactions underlying neurodegenerative diseases.
Publications
- An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 2007; (2): 201-15
- NFAT signaling and the invention of vertebrates. Trends Cell Biol. 2007; (6): 251-60
- NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21 Nature. 2006; (June 1): 595-600
- Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science. 2004; (5697): 865-9
- Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003; (5): 657-70
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