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Irving WeissmanAcademic Appointments
Appointment
Organization
Professor
Professor
Professor (By courtesy)
Member
Member
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Curriculum Vitae PDF
NIH Biosketch DocHonors & Awards
Title
Organization
Date(s)
The Linus Pauling Medal for Outstanding Contributions to Science
Stanford University
2005
Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research
The Lautenberg Center for General and Tumor Immunology
2004
Medal for Distinguished Contributions to Biomedical Research
New York Academy of Medicine
2004
Alan Cranston Awardee
Alliance for Aging Research
2004
Jessie Stevenson Kovalenko Medal
National Academy of Sciences Council
2004
8 honors and awards: view full list
Administrative Appointments
Title
Organization
Start Year
End Year
Director, Institute of Stem Cell Biology and Regenerative Medicine
Stanford University School of Medicine
2003
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Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
MD
Stanford University
Medicine
1965
BS
Montana State College
Pre-med
1961
Postdoctoral Advisees
Reza Ardehali,
Deepta Bhattacharya,
Alexander Boiko,
Keith Chan,
Micha Drukker,
Lauren Ehrlich,
Matthew Inlay,
Dongkyoon Kim,
Rong Lu,
Cynthia Luppen,
Jun Seita,
Stefano Tiozzo,
Stephen Willingham
Research Interests
Irving L. Weissman's research encompasses the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems. His laboratory identified and isolated the blood-forming stem cell from mice, and has defined, by lineage analysis, the stages of development between the stem cells and mature progeny (granulocytes, macrophages, etc.). This required developing and cloning stromal cells of the hematolymphoid microenvironments—from the bone marrow for myeloid and B cells, and from the thymus for T cells. While the adhesion molecules and factors from these stromal cells proved important as molecules (and the genes that encode them) for myeloid and B cells, the analysis of T cell development required in vivo studies of thymic development. In addition, the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo, either as a normal function or as events involved in malignant leukemic metastases.
The Weissman laboratory also has a small group at Hopkins Marine Station, where they have developed a model organism for laboratory and field study of allorecognition—the invertebrate counterpart of transplantation immunity. Working with the protochordate Botryllus schlosseri (which has a chordate larval stage and an invertebrate adult form) they have identified a single major gene locus that governs rapid allorecognition, and 2-3 other loci involved in delayed allorecognition events. They are using this model to study the genes, proteins, and cells that govern protochordate allorecognition, and the effects of these genes on their population dynamics in the field.
The Weissman laboratory also has a small group at Hopkins Marine Station, where they have developed a model organism for laboratory and field study of allorecognition—the invertebrate counterpart of transplantation immunity. Working with the protochordate Botryllus schlosseri (which has a chordate larval stage and an invertebrate adult form) they have identified a single major gene locus that governs rapid allorecognition, and 2-3 other loci involved in delayed allorecognition events. They are using this model to study the genes, proteins, and cells that govern protochordate allorecognition, and the effects of these genes on their population dynamics in the field.
Publications
- Hosen N, Park CY, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, Krensky AM, Weissman IL "CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia." Proc Natl Acad Sci U S A 2007; 104: 26: 11008-13 More »
- Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age." Nature 2007; 447: 7145: 725-9 More »
- Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL "Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis." Proc Natl Acad Sci U S A 2007; 104: 30: 12371-6 More »
- Czechowicz A, Kraft D, Weissman IL, Bhattacharya D "Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches." Science 2007; 318: 5854: 1296-9 More »
- Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E "New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3(+) multipotent hematopoietic progenitors." Cell 2006; 126: 2: 415-26 More »
283 publications: view full list
