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Harvey CohenAcademic Appointments
Appointment
Organization
Professor
Member
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Administrative Appointments
Title
Organization
Start Year
End Year
Chair
Stanford University School of Medicine - Pediatrics
1993
-
Postdoctoral Advisees
Brile Chung,
Dullei Min,
Silvestre Vicent,
Songyun Xu
Web Site Links
Research/Lab website:
The Harvey Cohen Lab
Research Interests
My research interests extend from hypothesis-driven studies in biochemistry and cell biology to discovery-driven interests in proteomics and systems biology to clinical treatment of acute lymphoblastic leukemia of children.
Our biochemical studies have centered on the identification and characterization of members of the glutathione peroxidase family of antioxidant enzymes that contain an enzymatically active selenocysteine residue within the primary structure of the protein.
Recently we have undertaken proteomic investigations whose aim is to identify differences in protein expression that may be biomarkers of diseases in children for which an unequivocal diagnostic test is unavailable, or there is little insight to the mechanism of the disease. This discovery-driven research is being used to identify proteins in plasma or urine of children with Kawasaki Disease, an inflammatory disorder that is the leading cause of acquired heart disease in the pediatric population. Other proteomic investigations are being performed in the areas of prematurity, neonatal disorders, acute lymphocytic and myelogenous leukemia, juvenile rheumatoid arthritis, and acquired respiratory distress syndromes.
My other clinical interests are found in hematologic and oncologic diseases of children, particularly acute lymphoblastic leukemia. Research is focused on optimization of multi-component chemotherapy and radiation treatment for these children. In addition, research investigations in pediatric palliative care have been initiated.
Our biochemical studies have centered on the identification and characterization of members of the glutathione peroxidase family of antioxidant enzymes that contain an enzymatically active selenocysteine residue within the primary structure of the protein.
Recently we have undertaken proteomic investigations whose aim is to identify differences in protein expression that may be biomarkers of diseases in children for which an unequivocal diagnostic test is unavailable, or there is little insight to the mechanism of the disease. This discovery-driven research is being used to identify proteins in plasma or urine of children with Kawasaki Disease, an inflammatory disorder that is the leading cause of acquired heart disease in the pediatric population. Other proteomic investigations are being performed in the areas of prematurity, neonatal disorders, acute lymphocytic and myelogenous leukemia, juvenile rheumatoid arthritis, and acquired respiratory distress syndromes.
My other clinical interests are found in hematologic and oncologic diseases of children, particularly acute lymphoblastic leukemia. Research is focused on optimization of multi-component chemotherapy and radiation treatment for these children. In addition, research investigations in pediatric palliative care have been initiated.
Publications
- Carlson SM, Najmi A, Whitin JC, Cohen HJ "Improving feature detection and analysis of surface-enhanced laser desorption/ionization-time of flight mass spectra." Proteomics 2005; More »
- Contro NA, Larson J, Scofield S, Sourkes B, Cohen HJ "Hospital staff and family perspectives regarding quality of pediatric palliative care." Pediatrics 2004; 114: 5: 1248-52 More »
- Cohen HJ, "Commentary on "Cancer incidence in adolescents and young adults in the United States, 1992-1997"." J Adolesc Health 2003; 32: 6: 403-4 More »
- Bhamre S, Whitin JC, Cohen HJ "Selenomethionine does not affect PSA secretion independent of its effect on LNCaP cell growth." Prostate 2003; 54: 4: 315-21 More »
- Whitin JC, Bhamre S, Tham DM, Cohen HJ "Extracellular glutathione peroxidase is secreted basolaterally by human renal proximal tubule cells." Am J Physiol Renal Physiol 2002; 283: 1: F20-8 More »
17 publications: view full list
